ArticleHuman brain mapping2017
Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: Modeling head motion and neuroanatomical specificity.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The State of Motion: Demographic and Representational Consequences of Motion-Based Exclusion in FMRI.bioRxiv : the preprint server for biology · 2026Article
- Altered functional connectivity of the hippocampus in cortico-subcortical networks in early-stage and emerging psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- An Open, Fully-processed, Longitudinal Data Resource to Study Brain Development and Transdiagnostic Executive Function.bioRxiv : the preprint server for biology · 2025Article
- Comparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Bridging the gap: improving correspondence between low-field and high-field magnetic resonance images in young people.Frontiers in neurology · 2024Article
- Large-Scale Neuroimaging of Mental Illness.Current topics in behavioral neurosciences · 2024Review
- Clinical and cortical similarities identified between bipolar disorder I and schizophrenia: A multivariate approach.Frontiers in human neuroscience · 2022Article
- What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.Human brain mapping · 2022Review
- Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders.Human brain mapping · 2021Article
- Detecting Abnormal Brain Regions in Schizophrenia Using Structural MRI via Machine Learning.Computational intelligence and neuroscience · 2020Article
- Structural Associations of Cortical Contrast and Thickness in First Episode Psychosis.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Linking Cortical and Connectional Pathology in Schizophrenia.Schizophrenia bulletin · 2019Article
- Head motion: the dirty little secret of neuroimaging in psychiatryJournal of psychiatry & neuroscience : JPN · 2019Article
- Cortical Surface Area Rather Than Cortical Thickness Potentially Differentiates Radiation Encephalopathy at Early Stage in Patients With Nasopharyngeal Carcinoma.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
Despite over 400 peer-reviewed structural MRI publications documenting neuroanatomic abnormalities in bipolar disorder and schizophrenia, the confounding effects of head motion and the regional specificity of these defects are unclear. Using a large cohort of individuals scanned on the same research dedicated MRI with broadly similar protocols, we observe reduced cortical thickness indices in both illnesses, though less pronounced in bipolar disorder. While schizophrenia (n = 226) was associated with wide-spread surface area reductions, bipolar disorder (n = 227) and healthy comparison subjects (n = 370) did not differ. We replicate earlier reports that head motion (estimated from time-series data) influences surface area and cortical thickness measurements and demonstrate that motion influences a portion, but not all, of the observed between-group structural differences. Although the effect sizes for these differences were small to medium, when global indices were covaried during vertex-level analyses, between-group effects became nonsignificant. This analysis raises doubts about the regional specificity of structural brain changes, possible in contrast to functional changes, in affective and psychotic illnesses as measured with current imaging technology. Given that both schizophrenia and bipolar disorder showed cortical thickness reductions, but only schizophrenia showed surface area changes, and assuming these measures are influenced by at least partially unique sets of biological factors, then our results could indicate some degree of specificity between bipolar disorder and schizophrenia. Hum Brain Mapp 38:3757-3770, 2017. © 2017 Wiley Periodicals, Inc.
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