ArticleNature communications2017
Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Electrophysiological differences in older and younger adults' anaphoric but not cataphoric pronoun processing in the absence of age-related behavioural slowdown.Scientific reports · 2020Trial
- Preserved topography, lateralization, selectivity, and functional connectivity of the language network in older brains.Nature communications · 2026Article
- Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia.Brain : a journal of neurology · 2026Article
- Language remains strongly left-lateralized in older adults: A cross-sectional and longitudinal study.bioRxiv : the preprint server for biology · 2026Article
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Age-Related Differences in Resting-State Functional Connectivity Predict Specific Patterns of Speech Disfluency.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Article
- When age tips the balance: A dual mechanism affecting hemispheric specialization for language.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Reorganization of structural connectivity in the brain supports preservation of cognitive ability in healthy aging.Network neuroscience (Cambridge, Mass.) · 2024Article
- The language network is not engaged in object categorization.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neurofunctional underpinnings of individual differences in visual episodic memory performance.Nature communications · 2023Article
- Domain-Specific Cognitive Impairment Reflects Prefrontal Dysfunction in Aged Common Marmosets.eNeuro · 2023Article
- Domain-specific cognitive impairment reflects prefrontal dysfunction in aged common marmosets.bioRxiv : the preprint server for biology · 2023Article
- Neural Contributions to Reduced Fluid Intelligence across the Adult Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the adult lifespan.Neurobiology of aging · 2023Article
- Does aging amplify the rule-based efficiency effect in action selection?Frontiers in psychology · 2023Article
- Differential effects of ageing on the neural processing of speech and singing production.Frontiers in aging neuroscience · 2023Article
- Multimodal fusion analysis of functional, cerebrovascular and structural neuroimaging in healthy aging subjects.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Healthy ageing has disparate effects on different cognitive domains. The neural basis of these differences, however, is largely unknown. We investigated this question by using Independent Components Analysis to obtain functional brain components from 98 healthy participants aged 23-87 years from the population-based Cam-CAN cohort. Participants performed two cognitive tasks that show age-related decrease (fluid intelligence and object naming) and a syntactic comprehension task that shows age-related preservation. We report that activation of task-positive neural components predicts inter-individual differences in performance in each task across the adult lifespan. Furthermore, only the two tasks that show performance declines with age show age-related decreases in task-positive activation of neural components and decreasing default mode (DM) suppression. Our results suggest that distributed, multi-component brain responsivity supports cognition across the adult lifespan, and the maintenance of this, along with maintained DM deactivation, characterizes successful ageing and may explain differential ageing trajectories across cognitive domains.
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