ArticleJournal of Korean medical science2017
Effects of Adrenal Androgen Levels on Bone Age Advancement in Prepubertal Children: Using the Ewha Birth and Growth Cohort Study.
Article in Journal of Korean medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Adrenal androgen mediates the association between obesity and accelerated skeletal maturation in children and adolescents.Frontiers in endocrinology · 2026Article
- Predicted Adult Height Remained Normal in Children With Premature Adrenarche Despite Advanced Bone Age.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche.Annals of pediatric endocrinology & metabolism · 2025Article
- Correlation of bone age development with overweight and obesity in 23,305 children from Beijing.Endocrine · 2025Article
- Association between sex hormones and bone age in boys aged 9-18 years from China.Journal of cellular and molecular medicine · 2024Article
- NMR-based metabolic profiling of children with premature adrenarche.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Analysis of the Relationship between Nutritional Status and Bone Age and Sexual Development in Children and Adolescents.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- An Approach to the Evaluation and Management of the Obese Child With Early Puberty.Journal of the Endocrine Society · 2022Review
- Androstenedione (a Natural Steroid and a Drug Supplement): A Comprehensive Review of Its Consumption, Metabolism, Health Effects, and Toxicity with Sex Differences.Molecules (Basel, Switzerland) · 2021Review
- Bone age in prepubertal children with nonfamilial or familial idiopathic short stature and prepubertal short-stature children born small for gestational age: a longitudinal data analysis.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2021Article
- Update on adrenarche.Current opinion in pediatrics · 2020Review
- Factors affecting bone maturation in Chinese girls aged 4-8 years with isolated premature thelarche.BMC pediatrics · 2020Article
- Morphometric signals of population decline in diademed sifakas occupying degraded rainforest habitat in Madagascar.Scientific reports · 2019Article
- Adult Height after Growth Hormone Treatment at Pubertal Onset in Short Adolescents Born Small for Gestational Age: Results from a Belgian Registry-Based Study.International journal of endocrinology · 2018Article
- Growth and Puberty in Obese Children and Implications of Body Composition.Journal of obesity & metabolic syndrome · 2017Review
- Health-related quality of life in children with congenital adrenal hyperplasia.Health and quality of life outcomes · 2017Article
- Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency.Annals of pediatric endocrinology & metabolism · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone age (BA) advancement in prepubertal children may be associated with earlier onset of puberty and obesity. This study aimed to define the effects of adrenal androgen levels on the advancement of BA in prepubertal children, independent of obesity. During July and August 2011, we examined BA in 200 prepubertal children aged 7-9 years who were part of the Ewha Birth & Growth Cohort Study. BA was assessed by the Greulich-Pyle method. An index of BA advancement was calculated as the ratio of BA to chronological age (CA) (BA/CA), and this ratio was classified into 3 tertiles. We analyzed the relationship between BA advancement and anthropometric characteristics and adrenal hormone levels. The number of overweight children increased from the first group to the third group (P(Trend) = 0.03). The levels of adrenal androgens showed a significant positive correlation with the tertile groups after adjusting for age and sex (testosterone: r = 0.26, P < 0.001; dehydroepiandrosterone: r = 0.21, P < 0.001; androstenedione: r = 0.20, P < 0.001). Further, after controlling for body mass index (BMI), sex, and age, the BA/CA was found to be positively correlated with androstenedione (β = 0.04, R² = 3.7%) and testosterone levels (β = 0.05, R² = 4.7%). Based on our results, it is suggested that adrenal androgen levels are associated with BA advancement independent of BMI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.