ArticleJournal of Korean medical science2017
Amplitude Modulation-based Electrical Stimulation for Encoding Multipixel Spatiotemporal Visual Information in Retinal Neural Activities.
Article in Journal of Korean medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Oscillatory Transcranial Electrical Stimulation and the Amplitude-Modulated Frequency Dictate the Quantitative Features of Phosphenes.The European journal of neuroscience · 2025Article
- Comparison of modulation efficiency between normal and degenerated primate retina.Frontiers in cell and developmental biology · 2024Article
- Editorial: Neuromodulation and neural technologies for sight restoration.Frontiers in cellular neuroscience · 2023Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- Electrical response of retinal ganglion cells in an N-methyl-N-nitrosourea-induced retinal degeneration porcine model.Scientific reports · 2021Article
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Authors and funding
5 authors.
Funding
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Abstract
Retinal implants have been developed as a promising way to restore partial vision for the blind. The observation and analysis of neural activities can offer valuable insights for successful prosthetic electrical stimulation. Retinal ganglion cell (RGC) activities have been investigated to provide knowledge on the requirements for electrical stimulation, such as threshold current and the effect of stimulation waveforms. To develop a detailed 'stimulation strategy' for faithful delivery of spatiotemporal visual information to the brain, it is essential to examine both the temporal and spatial characteristics of RGC responses, whereas previous studies were mainly focused on one or the other. In this study, we investigate whether the spatiotemporal visual information can be decoded from the RGC network activity evoked by patterned electrical stimulation. Along with a thorough characterization of spatial spreading of stimulation current and temporal information encoding, we demonstrated that multipixel spatiotemporal visual information can be accurately decoded from the population activities of RGCs stimulated by amplitude-modulated pulse trains. We also found that the details of stimulation, such as pulse amplitude range and pulse rate, were crucial for accurate decoding. Overall, the results suggest that useful visual function may be restored by amplitude modulation-based retinal stimulation.
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