ArticleJournal of magnetic resonance imaging : JMRI2018
Rapid and simultaneous measurement of phosphorus metabolite pool size ratio and reaction kinetics of enzymes in vivo.
Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Redox therapy for neuropsychiatric disorders: Molecular mechanisms and biomarker development.Science advances · 2026Review
- Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.Current psychiatry reports · 2023Review
- Bioenergetics and abnormal functional connectivity in psychotic disorders.Molecular psychiatry · 2021Article
- Creatine kinase rate constant in the human heart at 7T with 1D-ISIS/2D CSI localization.PloS one · 2020Article
- Is visual activation associated with changes in cerebral high-energy phosphate levels?Brain structure & function · 2018Article
- Quantitative imaging of brain energy metabolisms and neuroenergetics using in vivo X-nuclearJournal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeThe metabolites phosphocreatine (PCr), adenosine triphosphate (ATP), and in-organic phosphate (Pi) are biochemically coupled. Their pool sizes, assessed by their magnetization ratios, have been extensively studied and reflect bioenergetics status in vivo. However, most such studies have ignored chemical exchange and T MATERIALS AND
methodsModified Bloch-McConnell equations were used to simulate the effects of chemical exchanges on T
resultsThere were significant errors in underestimation of PCr/γATP by 12 % (P = 0.03) and overestimation of ATP/Pi ratios by 14 % (P = 0.04) when not considering chemical exchange effects. These errors were minimized using our iteration approach, resulting in no significant differences (PCr/γATP, P = 0.47; ATP/Pi, P = 0.81) in metabolite pool size ratios and reaction constants between the two measurements (i.e., short versus long TR conditions).
conclusionOur method can facilitate broad biomedical applications of LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:210-221.
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