Evidence map›Paper›PMID 28480581›Full record

ArticleMagnetic resonance in medicine2018

Automatic quantification of bone marrow edema on MRI of the wrist in patients with early arthritis: A feasibility study.

Evgeni Aizenberg, Edgar A H Roex, Wouter P Nieuwenhuis, Lukas Mangnus, Annette H M van der Helm-van Mil, Monique Reijnierse, Johan L Bloem, Boudewijn P F Lelieveldt, Berend C Stoel

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In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Evgeni AizenbergDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Edgar A H RoexDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Wouter P NieuwenhuisDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Lukas MangnusDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Annette H M van der Helm-van MilDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Monique ReijnierseDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Johan L BloemDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Boudewijn P F LelieveldtDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Berend C StoelDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the feasibility of automatic quantification of bone marrow edema (BME) on MRI of the wrist in patients with early arthritis.

methodsFor 485 early arthritis patients (clinically confirmed arthritis of one or more joints, symptoms for less than 2 years), MR scans of the wrist were processed in three automatic stages. First, super-resolution reconstruction was applied to fuse coronal and axial scans into a single high-resolution 3D image. Next, the carpal bones were located and delineated using atlas-based segmentation. Finally, the extent of BME within each bone was quantified by identifying image intensity values characteristic of BME by fuzzy clustering and measuring the fraction of voxels with these characteristic intensities within each bone. Correlation with visual BME scores was assessed through Pearson correlation coefficient.

resultsPearson correlation between quantitative and visual BME scores across 485 patients was r=0.83, P<0.001.

conclusionsQuantitative measurement of BME on MRI of the wrist has the potential to provide a feasible alternative to visual scoring. Complete automation requires automatic detection and compensation of acquisition artifacts. Magn Reson Med 79:1127-1134, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Indexed as

AdolescentAdultAgedAged, 80 and overAlgorithmsArthritis, RheumatoidBone MarrowCluster AnalysisEdemaFeasibility StudiesFemaleHumansImaging, Three-DimensionalMaleMiddle AgedWristatlas-based segmentationbone marrow edemainflammationrheumatoid arthritissuperresolution reconstruction

Identifiers

PMID28480581
PMCPMC5811824

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.