ArticleJournal of veterinary internal medicine2017
Hyperfibrinolysis and Hypofibrinogenemia Diagnosed With Rotational Thromboelastometry in Dogs Naturally Infected With Angiostrongylus vasorum.
Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 66 citations in OpenAlex.
- Endoparasites in carnivores in Swiss zoological institutions between 2009 and 2024: evaluation of risk factors and deworming strategies.International journal for parasitology. Parasites and wildlife · 2026Article
- Proteomic Analysis of Endothelial Activation Induced by AdultAnimals : an open access journal from MDPI · 2026Article
- Retrospective evaluation of dogs presenting with hemothorax.Journal of veterinary internal medicine · 2026Article
- Increased metallopeptidase activity, compromised endothelial integrity and impaired pathogen recognition revealed by transcriptomics inCurrent research in parasitology & vector-borne diseases · 2026Article
- In vitro cytokine response of circulating mononuclear cells from healthy dogs to stage-specific antigens of Angiostrongylus vasorum.BMC veterinary research · 2025Article
- Host-specific vascular endothelial cell responses toFrontiers in cellular and infection microbiology · 2025Article
- Article
- First case of autochthonous Angiostrongylus vasorum infection in a Norwegian dog.Acta veterinaria Scandinavica · 2024Article
- Is theFrontiers in veterinary science · 2023Article
- Use of tranexamic acid in dogs with primary immune thrombocytopenia: A feasibility study.Frontiers in veterinary science · 2023Article
- Case report: Disseminated intravascular coagulation in a dog following treatment with melarsomine forFrontiers in veterinary science · 2023Article
- Fibrinolysis in Dogs with Intracavitary Effusion: A Review.Animals : an open access journal from MDPI · 2022Review
- Evaluation of the Effect of Storage Time on ROTEM SAnimals : an open access journal from MDPI · 2022Article
- Hemostatic Dysfunction in Dogs Naturally Infected withPathogens (Basel, Switzerland) · 2022Review
- Impact of general anesthesia on rotational thromboelastometry (ROTEM) parameters and standard plasmatic coagulation tests in healthy Beagle dogs.Veterinary and animal science · 2021Article
- Fox Serum Proteomics Analysis Suggests Host-Specific Responses toPathogens (Basel, Switzerland) · 2021Article
- Highly Variable Clinical Pictures in Dogs Naturally Infected withPathogens (Basel, Switzerland) · 2021Article
- Coagulation Status in Dogs Naturally Infected withPathogens (Basel, Switzerland) · 2021Article
- Investigation of the occurrence ofJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Quantitative proteomics analysis of Angiostrongylus vasorum-induced alterations in dog serum sheds light on the pathogenesis of canine angiostrongylosis.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathomechanism of Angiostrongylus vasorum infection-associated bleeding diathesis in dogs is not fully understood.
objectiveTo describe rotational thromboelastometry (ROTEM) parameters in dogs naturally infected with A. vasorum and to compare ROTEM parameters between infected dogs with and without clinical signs of bleeding. ANIMALS: A total of 21 dogs presented between 2013 and 2016.
methodsDogs with A. vasorum infection and ROTEM evaluation were retrospectively identified. Thrombocyte counts, ROTEM parameters, clinical signs of bleeding, therapy, and survival to discharge were retrospectively retrieved from patient records and compared between dogs with and without clinical signs of bleeding.
resultsEvaluation by ROTEM showed hyperfibrinolysis in 8 of 12 (67%; 95% CI, 40-86%) dogs with and 1 of 9 (11%; 95% CI, 2-44%) dogs without clinical signs of bleeding (P = .016). Hyperfibrinolysis was associated with severe hypofibrinogenemia in 6 of 10 (60%; 95% CI, 31-83%) of the cases. Hyperfibrinolysis decreased or resolved after treatment with 10-80 mg/kg tranexamic acid. Fresh frozen plasma (range, 14-60 mL/kg) normalized follow-up fibrinogen function ROTEM (FIBTEM) maximal clot firmness in 6 of 8 dogs (75%; 95% CI, 41-93%). Survival to discharge was 67% (14/21 dogs; 95% CI, 46-83%) and was not different between dogs with and without clinical signs of bleeding (P = .379). CONCLUSION AND CLINICAL IMPORTANCE: Hyperfibrinolysis and hypofibrinogenemia were identified as an important pathomechanism in angiostrongylosis-associated bleeding in dogs. Hyperfibrinolysis and hypofibrinogenemia were normalized by treatment with tranexamic acid and plasma transfusions, respectively.
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