ArticleInternational journal of bipolar disorders2017
Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups.
Article in International journal of bipolar disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Characterization of Bipolar Disorder I and II: Clinical Features, Comorbidities, and Pharmacological Pattern.Alpha psychiatry · 2024Article
- Characterisation of age and polarity at onset in bipolar disorder.The British journal of psychiatry : the journal of mental science · 2021Article
- Early age of onset of mood, anxiety and alcohol use disorders is associated with sociodemographic characteristics and health outcomes in adults: results from a cross-sectional national survey.Social psychiatry and psychiatric epidemiology · 2021Article
- Predominant Polarity and Polarity Index of Maintenance Treatments for Bipolar Disorder: A Validation Study in a Large Naturalistic Sample in Italy.Medicina (Kaunas, Lithuania) · 2021Article
- Bipolar disorder: Trimodal age-at-onset distribution.Bipolar disorders · 2021Review
- Clinical Severity and Calcium Metabolism in Patients with Bipolar Disorder.Brain sciences · 2020Article
- Cannabis Use and Hypomania in Young People: A Prospective Analysis.Schizophrenia bulletin · 2018Article
- White Matter Microstructural Changes and Episodic Memory Disturbances in Late-Onset Bipolar Disorder.Frontiers in psychiatry · 2018Article
- We're not in Kansas anymore: ectopic dopaminergic terminals as an explanation for the positive symptoms in psychiatric pathology.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdmixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO as well as the clinical features of EO BD type 1 (BD1) with EO BD type 2 (BD2). To this end, we studied 515 BD patients (224 BD1, 279 BD2, and 12 BD not otherwise specified [NOS]) diagnosed according to DSM-IV-TR criteria.
methodsAAO was defined as the first reliably diagnosed hypo/manic or depressive episode according to diagnostic criteria. We used normal distribution mixture analysis to identify subgroups of patients according to AAO. Models were chosen according to the Schwarz's Bayesian information criteria (BIC). Clinical correlates of EO were analysed using univariate tests and multivariate logistic regression models.
resultsA two normal components model best fitted the observed distribution of AAO in BD1 (BIC = -1599.3), BD2 (BIC = -2158.4), and in the whole sample (BIC = -3854.9). A higher number of EO BD2 patients had a depression-(hypo)mania-free interval (DMI) course, while a higher rate of (hypo)mania-depression-free interval (MDI) course was found in EO BD1. EO BD2 had also a higher rate of comorbidity with alcohol dependence compared to EO BD1. The latter finding was confirmed by multivariate logistic regression analysis.
conclusionsIn conclusion, both BD1 and BD2 had bimodal AAO distributions, but EO subgroups had a diagnostic-specific clinical delineation.
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