Evidence map›Paper›PMID 28480336›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017

Longitudinal relationships among activity in attention redirection neural circuitry and symptom severity in youth.

Michele A Bertocci, Genna Bebko, Amanda Dwojak, Satish Iyengar, Cecile D Ladouceur, Jay C Fournier, Amelia Versace, Susan B Perlman, Jorge R C Almeida, Michael J Travis and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Michele A BertocciDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Genna BebkoDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Amanda DwojakDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Satish IyengarDepartment of Psychology, University of Pittsburgh.
Cecile D LadouceurDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Jay C FournierDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Amelia VersaceDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Susan B PerlmanDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Jorge R C AlmeidaAlpert Medical School, Brown University.
Michael J TravisDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Mary Kay GillDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Lisa BonarDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Claudiu SchirdaDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
Vaibhav A DiwadkarDepartment of Psychiatry and Behavioral Neuroscience, Wayne State University.
Jeffrey L SunshineUniversity Hospitals Case Medical Center/Case Western Reserve University.
Scott K HollandCincinnati Children's Hospital Medical Center, University of Cincinnati.
Robert A KowatchThe Research Institute at Nationwide Children's Hospital.
Boris BirmaherDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.
David AxelsonThe Research Institute at Nationwide Children's Hospital.
Sarah M HorwitzDepartment of Child Psychiatry, New York University School of Medicine.
Thomas FrazierDepartment of Psychiatry, Ohio State University.
L Eugene ArnoldDepartment of Psychiatry and Behavioral Health, Ohio State University.
Mary A FristadDepartment of Psychiatry, Ohio State University.
Eric A YoungstromDepartment of Psychology, University of North Carolina at Chapel Hill.
Robert L FindlingUniversity Hospitals Case Medical Center/Case Western Reserve University.
Mary L PhillipsDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh.

Funding

Longitudinal Assessment of Manic SymptomsR01MH073967 · NIMH · JOHNS HOPKINS UNIVERSITY · PI FINDLING, ROBERT L · 2005 to 2016
$11.4M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073953 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2005 to 2016
$8.7M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073816 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI HOLLAND, SCOTT K. · 2005 to 2016
$5.9M
Longitudinal Assessment of Manic Symptoms (LAMS) StudyR01MH073801 · NIMH · OHIO STATE UNIVERSITY · PI FRISTAD, MARY A · 2005 to 2016
$5.9M
Neural Markers of Individual Difference in Emotion Regulation in Depressed AdultsK23MH097889 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOURNIER, JAY C · 2013 to 2017
$786k
NIMH NIH HHS K23 MH097889NIMH NIH HHS R01 MH073801NIMH NIH HHS R01 MH073816NIMH NIH HHS R01 MH073953NIMH NIH HHS R01 MH073967
6 · The paper itself

Abstract

backgroundChanges in neural circuitry function may be associated with longitudinal changes in psychiatric symptom severity. Identification of these relationships may aid in elucidating the neural basis of psychiatric symptom evolution over time. We aimed to distinguish these relationships using data from the Longitudinal Assessment of Manic Symptoms (LAMS) cohort.

methodsForty-one youth completed two study visits (mean=21.3 months). Elastic-net regression (Multiple response Gaussian family) identified emotional regulation neural circuitry that changed in association with changes in depression, mania, anxiety, affect lability, and positive mood and energy dysregulation, accounting for clinical and demographic variables.

resultsNon-zero coefficients between change in the above symptom measures and change in activity over the inter-scan interval were identified in right amygdala and left ventrolateral prefrontal cortex. Differing patterns of neural activity change were associated with changes in each of the above symptoms over time. Specifically, from Scan1 to Scan2, worsening affective lability and depression severity were associated with increased right amygdala and left ventrolateral prefrontal cortical activity. Worsening anxiety and positive mood and energy dysregulation were associated with decreased right amygdala and increased left ventrolateral prefrontal cortical activity. Worsening mania was associated with increased right amygdala and decreased left ventrolateral prefrontal cortical activity. These changes in neural activity between scans accounted for 13.6% of the variance; that is 25% of the total explained variance (39.6%) in these measures.

conclusionsDistinct neural mechanisms underlie changes in different mood and anxiety symptoms overtime.

Indexed as

behaviorally and emotionally dysregulated youthElastic-netemotional regulationlongitudinalneural mechanismpenalized regression

Identifiers

PMID28480336
PMCPMC5416876

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.