ArticleNature human behaviour2017
A unified model of human semantic knowledge and its disorders.
Article in Nature human behaviour, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dysfunctions associated with the intraparietal sulcus and a distributed network in individuals with math learning difficulties: An ALE meta-analysis.Human brain mapping · 2023Pooled it
- Neural representation of word categories is distinct in the temporal lobe: An activation likelihood analysis.Human brain mapping · 2018Pooled it
- E/I imbalance and internal noise cause weak neural representations and face recognition challenges in ASD.Communications biology · 2026Article
- Overlapping and distinct intrinsic connectivity of hippocampal and triple networks in autistic individuals with and without a comorbid condition of ADHD.Frontiers in psychiatry · 2026Article
- From cortical and white matter structure to meaning: a brain-constrained neural network of semantic grounding in action and perception.Frontiers in human neuroscience · 2026Article
- Controlled Semantic Cognition: Precision Recordings Converge With in Silico Experiments to Reveal the Inner Workings of the Anterior Temporal Lobe Hub.Neurobiology of language (Cambridge, Mass.) · 2026Review
- Semantic Representational Strength in the Precuneus and Lateral ATL Predicts Successful Factual Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Multimodal MEG and Microstructure-MRI Investigations of the Human Hippocampal Scene Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural mechanisms for the attention-mediated propagation of conceptual information in the human brain.PLoS biology · 2025Article
- Neural correlates of social and thematic semantics in autistic and non-autistic adults.Social cognitive and affective neuroscience · 2025Article
- Self-referential belief shares common neural correlates with general belief.Scientific reports · 2025Article
- Unaware processing of words activates experience-derived information in conceptual-semantic brain networks.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Using drawings and deep neural networks to characterize the building blocks of human visual similarity.Memory & cognition · 2025Article
- Clinical Manifestations and Neural Basis of Semantic Dementia: Converging Evidences From Brain Imaging Studies.Clinical interventions in aging · 2025Review
- The impact of bilateral versus unilateral anterior temporal lobe damage on face recognition, person knowledge and semantic memory.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Harmonic memory signals in the human cerebral cortex induced by semantic relatedness of words.NPJ science of learning · 2024Article
- Representation of event and object concepts in ventral anterior temporal lobe and angular gyrus.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Age-related differences in the intrinsic connectivity of the hippocampus and ventral temporal lobe in autistic individuals.Frontiers in human neuroscience · 2024Article
- Representational similarity learning reveals a graded multidimensional semantic space in the human anterior temporal cortex.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The left posterior angular gyrus is engaged by autobiographical recall not object-semantics, or event-semantics: Evidence from contrastive propositional speech production.Imaging neuroscience (Cambridge, Mass.) · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
How is knowledge about the meanings of words and objects represented in the human brain? Current theories embrace two radically different proposals: either distinct cortical systems have evolved to represent different kinds of things, or knowledge for all kinds is encoded within a single domain-general network. Neither view explains the full scope of relevant evidence from neuroimaging and neuropsychology. Here we propose that graded category-specificity emerges in some components of the semantic network through joint effects of learning and network connectivity. We test the proposal by measuring connectivity amongst cortical regions implicated in semantic representation, then simulating healthy and disordered semantic processing in a deep neural network whose architecture mirrors this structure. The resulting neuro-computational model explains the full complement of neuroimaging and patient evidence adduced in support of both domain-specific and domain-general approaches, reconciling long-standing disputes about the nature and origins of this uniquely human cognitive faculty.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.