Evidence map›Paper›PMID 28480314›Full record

ArticleTranslational perioperative and pain medicine2016

Biomarkers for Chronic Neuropathic Pain and their Potential Application in Spinal Cord Stimulation: A Review.

Chibueze D Nwagwu, Christina Sarris, Yuan-Xiang Tao, Antonios Mammis

Registry-linked trialAbstract read
In one paragraph

Article in Translational perioperative and pain medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06030297 (Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06030297 nacompletednot on this mapstarted 2023, after this paper: background citation

Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.

TypeinterventionalSponsorUniversity of UtahRan2023 to 2026Enrolled75ConditionsPeripheral NeuropathyArmsDiode Laser fiber type Selective Stimulator, ZTlido 1.8 % Topical System, PeriCam PSI NR, Medoc Quantitative Sensory Testing, Inactive Topical System
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Association between obesity and craniofacial muscles sensitivity: an experimental study in pain-free subjects.International journal of physiology, pathophysiology and pharmacology · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chibueze D NwagwuDepartment of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Christina SarrisBarrow Neurological Institute, Phoenix, Arizona, USA.
Yuan-Xiang TaoDepartment of Anesthesiology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Antonios MammisDepartment of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Funding

The Role of Endothelin-1 in Sickle Cell DiseaseU01HL117684 · NHLBI · AUGUSTA UNIVERSITY · PI KUTLAR, ABDULLAH, MEILER, STEFFEN · 2013 to 2017
$8.1M
Epigenetic regulation of neuropathic pain: Role of DRG histone methyltransferase G9aR01NS094664 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2016 to 2020
$2.0M
mTOR, a new target for opioid-induced tolerance and hyperalgesiaR01DA033390 · NIDA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2013 to 2017
$1.8M
Epigenetic Regulation of Neuropathic Pain: Role of Native Kv1.2 Antisense RNAR01NS072206 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2011 to 2014
$1.4M
NHLBI NIH HHS U01 HL117684NIDA NIH HHS R01 DA033390NINDS NIH HHS R01 NS072206NINDS NIH HHS R01 NS094664
6 · The paper itself

Abstract

This review was focused on understanding which substances inside the human body increase and decrease with increasing neuropathic pain. We reviewed various studies, and saw correlations between neuropathic pain and components of the immune system (this system defends the body against diseases and infections). Our findings will especially be useful for understanding ways to reduce or eliminate the discomfort, chronic neuropathic pain brings with it. Spinal cord stimulation (SCS) procedure is one of the few fairly efficient remedial treatments for pain. A follow-up study will apply our findings from this review to SCS, in order to understand the mechanism, and further optimize efficaciousness.

Indexed as

chronic neuropathic paincytokinespain biomarkersspinal cord stimulation

Identifiers

PMID28480314
PMCPMC5415348

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.