ArticleOpen forum infectious diseases2017
Clinical Utility of the Nonstructural 1 Antigen Rapid Diagnostic Test in the Management of Dengue in Returning Travelers With Fever.
Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Autochthonous dengue transmission in Europe: epidemiology, mechanisms, and modelling insights.Biology direct · 2026Review
- Dengue and severe dengue.Clinical microbiology reviews · 2025Review
- Neurological Manifestations of Perinatal Dengue.Newborn (Clarksville, Md.) · 2023Article
- Response to: Adrenal haemorrhage and COVID-19 vaccine-induced immune thrombotic thrombocytopenia: correspondence.QJM : monthly journal of the Association of Physicians · 2022Article
- The Emergence of Travel-related Infections in Critical Care Units.Journal of translational internal medicine · 2022Article
- Neurological Complications of Dengue Fever.Current neurology and neuroscience reports · 2022Review
- Article
- Impact of Dengue Rapid Diagnostic Tests on the Prescription of Antibiotics and Anti-Inflammatory Drugs by Physicians in an Endemic Area in Colombia.The American journal of tropical medicine and hygiene · 2019Article
- [Dengue fever : Symptoms, epidemiology, entomology, pathogen diagnosis and prevention].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2017Review
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid diagnostic test (RDT) detecting the nonstructural 1 (NS1) antigen is increasingly used for dengue diagnosis in endemic and nonendemic settings, but its clinical utility has not been studied in travel clinic practice.
methodsFrom August 2012 to July 2016, travelers returning from the tropics with fever were evaluated in the Institute of Tropical Medicine (Antwerp, Belgium) with the routine use of NS1 antigen RDT that provided results within 1 hour. We determined the diagnostic performance, assessed the management of patients with a positive RDT result, and compared it with that of historical cases of dengue diagnosed from 2000 to 2006, when only antibody detection assays were available.
resultsOf 335 travelers evaluated for fever, 54 (16%) were diagnosed with dengue, including 1 severe case. Nonstructural 1 antigen RDT was performed in 308 patients. It was truly positive in 43 of 52 tested dengue cases and falsely positive in only 1 of the 256 nondengue cases; therefore, sensitivity was 82.7% (95% confidence interval [CI], 74.4%-93.0%) and specificity was 99.6% (95% CI, 98.8%-100%). Only 3 (7%) of the 43 febrile travelers "immediately" diagnosed by RDT were admitted, and only 2 (5%) were given empirical antibacterial treatment, without adverse outcome. Admission and antibiotic prescription rates were significantly higher in the historical cases (n = 43) diagnosed by antibody detection (33%,
conclusionsIn our practice, the diagnostic performance of NS1 antigen RDT substantially contributed in withholding unnecessary hospitalization and antibiotherapy in dengue patients.
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