Evidence map›Paper›PMID 28480226›Full record

ArticleCancer research frontiers2016

In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation.

Gemma L Robinson, Beatrice Philip, Matthew R Guthrie, James E Cox, James P Robinson, Matthew W VanBrocklin, Sheri L Holmen

Open access · greenAbstract read
In one paragraph

Article in Cancer research frontiers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Novel Insights for Inhibiting Mutant Heterodimer IDH1Molecular diagnosis & therapy · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gemma L RobinsonDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA.
Beatrice PhilipDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA.
Matthew R GuthrieDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA.
James E CoxMetabolomics Core Research Facility, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
James P RobinsonThe Hormel Institute, University of Minnesota, Austin, MN, 55912, USA.
Matthew W VanBrocklinDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA.
Sheri L HolmenDepartment of Surgery, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA.
Huntsman Cancer Institute · USHormel (United States) · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Defining the role of mutant IDH in glioma initiation and maintenanceR01NS075155 · NINDS · UNIVERSITY OF UTAH · PI HOLMEN, SHERI L · 2011 to 2016
$1.7M
Defining the role of BRAF in glioma initiation and maintenanceR01NS073870 · NINDS · UNIVERSITY OF UTAH · PI HOLMEN, SHERI L · 2011 to 2016
$1.7M
LINEAR ION-TRAP /FOURIER TRANSFORM MASS SPECTROMETER: PROTEOMICS: DIABETESS10RR020883 · NCRR · UNIVERSITY OF UTAH · PI NELSON, CHAD C · 2005 to 2005
$500k
Maldi/ToF/ToF Mass Spectrometer for the University of UtahS10RR025532 · NCRR · UNIVERSITY OF UTAH · PI NELSON, CHAD C · 2010 to 2010
$490k
NCRR Confocal ProposalS10RR024761 · NCRR · UNIVERSITY OF UTAH · PI RODESCH, CHRISTOPHER K · 2008 to 2008
$475k
NCI NIH HHS P30 CA042014NCRR NIH HHS S10 RR020883NCRR NIH HHS S10 RR024761NCRR NIH HHS S10 RR025532NINDS NIH HHS R01 NS073870NINDS NIH HHS R01 NS075155
6 · The paper itself

Abstract

Mutations in the metabolic enzyme

Indexed as

bimolecular fluorescence complementation (BiFC)fluorescent imagingisocitrate dehydrogenase (IDH)malignant gliomaprotein-protein interactions

Identifiers

PMID28480226
PMCPMC5417691
OpenAlexW2465809365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.