Evidence map›Paper›PMID 28479756›Full record

ArticleJournal of human reproductive sciences

Relationship Between Morphology, Euploidy and Implantation Potential of Cleavage and Blastocyst Stage Embryos.

Gaurav Majumdar, Abha Majumdar, Ishwar C Verma, Kailash C Upadhyaya

Erratum issued Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05919186 (Impact of Repeated Antioxidant Supplementation of Embryo Culture Media on Blastocyst Utilization and Expansion Rate Under Two Different O2 Concentrations), which is not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05919186 nacompletednot on this map

Impact of Repeated Antioxidant Supplementation of Embryo Culture Media on Blastocyst Utilization and Expansion Rate Under Two Different O2 Concentrations

TypeinterventionalSponsorLiliana Berenice Ramírez DomínguezRan2021 to 2022Enrolled293ConditionsInfertility, Female, Infertility, MaleArmsEmbryORP®, O2 tension 20%, O2 tension 5%
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  10. Noninvasive Biomarkers of Human Embryo Developmental Potential.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Gaurav MajumdarCenter of IVF and Human Reproduction, Institute of Obstetrics and Gynaecology, New Delhi, Delhi, India.
Abha MajumdarCenter of IVF and Human Reproduction, Institute of Obstetrics and Gynaecology, New Delhi, Delhi, India.
Ishwar C VermaCenter of Medical Genetics, Sir Ganga Ram Hospital, New Delhi, Delhi, India.
Kailash C UpadhyayaAmity Institute of Molecular Biology and Genomics, Amity University, Noida, UP, India.
Institute for Human Development · INAmity University · INSir Ganga Ram Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of this study was to investigate the relationship between the morphology, euploidy and implantation rate of cleavage stage and blastocyst stage embryos.

settingInstitution-based, tertiary care STUDY

designThis study included a retrospective data analysis of 306 embryos: 154 cleavage stage embryos and 152 blastocysts that underwent biopsy on day 3 and day 5/6, respectively, which were subsequently screened for aneuploidy by array comparative genomic hybridization analysis. MATERIALS AND

methodsBoth cleavage stage and blastocyst stage embryos were categorized according to their morphology into the following three groups: good, average and poor. In addition, blastocysts were categorized into day 5 and day 6 embryos on the basis of their developmental rate.

resultsThe euploidy rate was found to be significantly higher for blastocysts with good morphology as compared to those with poor morphology, with 73.2, 50 and 40.5% euploid embryos in the good, average and poor morphology groups, respectively (

conclusionBlastocyst morphology and the rate of development were found to be significantly associated with euploidy, whereas cleavage stage morphology was not. The implantation rates of the good quality, euploid cleavage stage embryos were higher than that of the poor quality embryos. The implantation rates were similar for all transferred euploid blastocysts, irrespective of their morphology or the rate of development.

Indexed as

Aneuploidyblastocystcleavage stage embryoimplantation ratemorphologypreimplantation genetic screening

Identifiers

PMID28479756
PMCPMC5405648
OpenAlexW2681240823

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.