ReviewNeuropharmacology2017
Effects of acute alcohol on excitability in the CNS.
Review in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Alcohol and Neural Dynamics: A Meta-analysis of Acute Alcohol Effects on Event-Related Brain Potentials.Biological psychiatry · 2021Pooled it
- The neurobiological markers of acute alcohol's subjective effects in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data.Addiction biology · 2022Trial
- An autopsy case of diphenhydramine overdose with drug concentration data from multiple samples sites.Forensic science, medicine, and pathology · 2026Article
- ER Stress Regulates HIV Tat and Alcohol-Induced NLRP6 Activation in Astrocytes.CNS neuroscience & therapeutics · 2026Article
- Prevalence of Chronic Pain and Associated Factors Among Nursing Students in Heilongjiang Province, China: A Cross-Sectional Study.Nursing open · 2026Article
- Activation by Alcohol of Prefrontal Layer 5 Pyramidal Neurons Depends on Ascending Dopaminergic Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Alcohol and Opioids Modulate Excitatory Inputs to the SCN.bioRxiv : the preprint server for biology · 2026Article
- Cholesterol and docosahexaenoic acid likely protect against alcohol-induced constriction of cerebral arteries via a common pathway.Advances in drug and alcohol research · 2026Article
- Electrophysiological data showing the acute alcohol effect on neuronal excitability in the murine posterior parietal cortex.Data in brief · 2025Article
- Alcohol Facilitates Social Dominance Via Activating Dopamine 1 Receptor-expressing Neurons in the Lateral Septum of Male Mice.Molecular neurobiology · 2025Article
- Synergistic enhancement of detection-tracking framework for zebrafish shoaling behavior analysis.Scientific reports · 2025Article
- Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake.Alcohol (Fayetteville, N.Y.) · 2025Review
- Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation.iScience · 2025Article
- Alcohol consumption drives sex- and region- specific disruption of somatostatin signaling in mice.bioRxiv : the preprint server for biology · 2025Article
- Moderate prenatal alcohol exposure alters GABAergic transmission and the actions of acute alcohol in the medial central amygdala of adolescent rats.Neuropharmacology · 2025Article
- Toluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms.Annual review of pharmacology and toxicology · 2025Review
- Impact of pre-trauma recreational drug use on mental health outcomes among survivors of the Israeli Nova Festival terrorist attack.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits.Life sciences · 2024Article
- A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging.Neuropharmacology · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Alcohol has many effects on brain function and hence on human behavior, ranging from anxiolytic and mild disinhibitory effects, sedation and motor incoordination, amnesia, emesis, hypnosis and eventually unconsciousness. In recent years a variety of studies have shown that acute and chronic exposure to alcohol can modulate ion channels that regulate excitability. Modulation of intrinsic excitability provides another way in which alcohol can influence neuronal network activity, in addition to its actions on synaptic inputs. In this review, we review "low dose" effects [between 2 and 20 mM EtOH], and "medium dose"; effects [between 20 and 50 mM], by considering in turn each of the many networks and brain regions affected by alcohol, and thereby attempt to integrate in vitro physiological studies in specific brain regions (e.g. amygdala, ventral tegmental area, prefrontal cortex, thalamus, cerebellum etc.) within the context of alcohol's behavioral actions in vivo (e.g. anxiolysis, euphoria, sedation, motor incoordination). This article is part of the Special Issue entitled "Alcoholism".
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.