ArticleThe Journal of allergy and clinical immunology2018
Forkhead box protein 3 demethylation is associated with tolerance induction in peanut-induced intestinal allergy.
Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Randomized controlled trial on the influence of dietary intervention on epigenetic mechanisms in children with cow's milk allergy: the EPICMA study.Scientific reports · 2019Trial
- The immunobiology and therapeutic potential of regulatory T cells in autoimmune diseases and allergic diseases.Frontiers in immunology · 2025Review
- The First 1000 Days of Life: How Changes in the Microbiota Can Influence Food Allergy Onset in Children.Nutrients · 2023Review
- Intestinal factors promoting the development of RORγtFrontiers in immunology · 2023Review
- Epigenetics in Food Allergy and Immunomodulation.Nutrients · 2021Review
- The Interplay of Nutriepigenomics, Personalized Nutrition and Clinical Practice in Managing Food Allergy.Life (Basel, Switzerland) · 2021Review
- Article
- Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development.Biomolecules · 2021Review
- Exosomes of pasteurized milk: potential pathogens of Western diseases.Journal of translational medicine · 2019Review
- Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy.Nature communications · 2018Article
- New modalities of allergen immunotherapy.Human vaccines & immunotherapeutics · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRegulatory T (Treg) cells play an essential role in the maintenance of immune homeostasis in allergic diseases.
objectivesWe sought to define the mechanisms underlying induction of tolerance to peanut protein and prevention of the development of peanut allergy.
methodsHigh or low doses of peanut extract were administered to pups every day for 2 weeks before peanut sensitization and challenge. After challenge, symptoms, Treg cell numbers, and forkhead box protein 3 (Foxp3), T
resultsFeeding high but not low doses of peanut before sensitization induced tolerance, as demonstrated by prevention of diarrhea and peanut-specific IgE responses, increases in the percentage of CD4
conclusionsFeeding high doses of peanut to pups induced tolerance to peanut protein. Foxp3 demethylation was associated with tolerance induction, indicating that Treg cells play an important role in the regulation of peanut sensitivity and maintenance of immune homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.