ArticleClinica chimica acta; international journal of clinical chemistry2017
Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS/MS: Impact of gender, age, oral contraceptives, body mass index and blood pressure status.
Article in Clinica chimica acta; international journal of clinical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 167 citations in OpenAlex.
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- Clinical diagnostic value of liquid chromatography-tandem mass spectrometry method for primary aldosteronism in patients with hypertension: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Open-label placebos reduce hair cortisol concentrations and psychological distress - a randomized controlled trial.Scientific reports · 2026Trial
- A randomized vagus nerve stimulation study demonstrates that serum aldosterone levels decrease with age in women, but not in men.Scientific reports · 2023Trial
- Residual Corticosteroid Production in Autoimmune Addison Disease.The Journal of clinical endocrinology and metabolism · 2020Trial
- Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity.Journal of internal medicine · 2026Article
- Approach to the patient: investigation of postmenopausal androgen excess.The Journal of clinical endocrinology and metabolism · 2026Review
- When Good Biology Meets Negative Clinical Trials: Lessons from PHANTOM and EDIPHY.Annals of the American Thoracic Society · 2026Article
- GnRH-receptor antagonism as a targeted approach to reproductive dysfunction in polycystic ovary syndrome.EBioMedicine · 2026Article
- Advanced machine learning-based screening for primary aldosteronism with plasma steroids, potassium, and renin.NPJ digital medicine · 2026Article
- Article
- Temporal organization of gonadal and adrenal steroid fluctuations in male mice.Endocrine connections · 2026Article
- Challenges and opportunities of wearable molecular sensors in endocrinology and metabolism.Nature reviews. Endocrinology · 2026Review
- Current insights into monitoring of congenital adrenal hyperplasia.Frontiers in endocrinology · 2026Review
- Plasma Steroid Profiles in Individuals With Class II/III Obesity: Association With Weight Loss After Metabolic Surgery.Journal of the Endocrine Society · 2025Article
- Robustness of steroidomics-based machine learning for diagnosis of primary aldosteronism: a laboratory medicine perspective.Clinical chemistry and laboratory medicine · 2025Article
- Eccentric training effects on hamstring muscles in oral contraceptive users and naturally menstruating women.European journal of applied physiology · 2025Article
- Artifactual elevations of 11β-hydroxyandrostenedione and 11-ketoandrostenedione in mass spectrometry assays.The Journal of steroid biochemistry and molecular biology · 2025Article
- Free Cortisol and Free 21-Deoxycortisol in the Clinical Evaluation of Congenital Adrenal Hyperplasia.The Journal of clinical endocrinology and metabolism · 2025Article
- Not Just Corticosterone: Further Characterization of the Endocrine Response of Kemp's Ridley Sea Turtles (Animals : an open access journal from MDPI · 2025Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMass spectrometric-based measurements of the steroid metabolome have been introduced to diagnose disorders featuring abnormal steroidogenesis. Defined reference intervals are important for interpreting such data.
methodsLiquid chromatography-tandem mass spectrometry was used to establish reference intervals for 16 steroids (pregnenolone, progesterone, 11-deoxycorticosterone, corticosterone, aldosterone, 18-oxocortisol, 18-hydroxycortisol, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androstenedione, testosterone) measured in plasma from 525 volunteers with (n=227) and without (n=298) hypertension, including 68 women on oral contraceptives.
resultsWomen showed variable plasma concentrations of several steroids associated with menstrual cycle phase, menopause and oral contraceptive use. Progesterone was higher in females than males, but most other steroids were higher in males than females and almost all declined with advancing age. Using models that corrected for age and gender, body mass index showed weak negative relationships with corticosterone, 21-deoxycortisol, cortisol, cortisone, testosterone, progesterone, 17-hydroxyprogesterone and 11-deoxycorticosterone, but a positive relationship with 18-hydroxycortisol. Hypertensives and normotensives showed negligible differences in plasma concentrations of steroids.
conclusionAge and gender are the most important variables for plasma steroid reference intervals, which have been established here according to those variables for a panel of 16 steroids primarily useful for diagnosis and subtyping of patients with endocrine hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.