Evidence map›Paper›PMID 28479305›Full record

ArticleStem cell reports2017

Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury.

Katja M Piltti, Gabriella M Funes, Sabrina N Avakian, Ara A Salibian, Kevin I Huang, Krystal Carta, Noriko Kamei, Lisa A Flanagan, Edwin S Monuki, Nobuko Uchida and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Rewiring the Spine-Cutting-Edge Stem Cell Therapies for Spinal Cord Repair.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Two-dimensional TiJournal of nanobiotechnology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Multifunctionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Katja M PilttiSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Physical & Medical Rehabilitation, University of California Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments & Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA. Electronic address: kpiltti@uci.edu.
Gabriella M FunesSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Anatomy & Neurobiology, University of California Irvine, Irvine, CA 92697, USA.
Sabrina N AvakianSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Anatomy & Neurobiology, University of California Irvine, Irvine, CA 92697, USA.
Ara A SalibianSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA.
Kevin I HuangSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Anatomy & Neurobiology, University of California Irvine, Irvine, CA 92697, USA.
Krystal CartaSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA.
Noriko KameiSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Physical & Medical Rehabilitation, University of California Irvine, Irvine, CA 92697, USA.
Lisa A FlanaganSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments & Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA; Anatomy & Neurobiology, University of California Irvine, Irvine, CA 92697, USA; Department of Biomedical Engineering, University of California Irvine, Irvine, CA 92697, USA; Department of Neurology, University of California Irvine, Irvine, CA 92697, USA.
Edwin S MonukiSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments & Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA; Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA 92697, USA.
Nobuko UchidaBOCO Silicon Valley, ReGen Med Division, Palo Alto, CA 94303, USA.
Brian J CummingsSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Physical & Medical Rehabilitation, University of California Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments & Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA; Anatomy & Neurobiology, University of California Irvine, Irvine, CA 92697, USA.
Aileen J AndersonSue & Bill Gross Stem Cell Center, University of California Irvine, Irvine, CA 92697, USA; Physical & Medical Rehabilitation, University of California Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments & Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA; Anatomy & Neurobiology, University of California Irvine, Irvine, CA 92697, USA.

Funding

Mechanisms of SCI Recovery after hCNS Stem Cell GraftsR01NS049885 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSON, AILEEN J · 2004 to 2008
$1.4M
NINDS NIH HHS R01 NS049885
6 · The paper itself

Abstract

Multipotent human central nervous system-derived neural stem cells transplanted at doses ranging from 10,000 (low) to 500,000 (very high) cells differentiated predominantly into the oligodendroglial lineage. However, while the number of engrafted cells increased linearly in relationship to increasing dose, the proportion of oligodendrocytic cells declined. Increasing dose resulted in a plateau of engraftment, enhanced neuronal differentiation, and increased distal migration caudal to the transplantation sites. Dose had no effect on terminal sensory recovery or open-field locomotor scores. However, total human cell number and decreased oligodendroglial proportion were correlated with hindlimb girdle coupling errors. Conversely, greater oligodendroglial proportion was correlated with increased Ab step pattern, decreased swing speed, and increased paw intensity, consistent with improved recovery. These data suggest that transplant dose, and/or target niche parameters can regulate donor cell engraftment, differentiation/maturation, and lineage-specific migration profiles.

Indexed as

Cell DifferentiationAnimalsAntigens, NuclearCell LineageCell MovementCells, CulturedCellular MicroenvironmentGene ExpressionHumansMiceMice, Inbred NODMice, SCIDMicrotubule-Associated ProteinsNerve Tissue ProteinsNeural Stem CellsNeuronsAntigens, NuclearARTN protein, humanMAP2 protein, humanMicrotubule-Associated ProteinsNerve Tissue Proteinsneuronal nuclear antigen NeuN, humanOLIG2 protein, humanOligodendrocyte Transcription Factor 2cell dosedifferentiationfatehuman neural stem cellmicroenvironmentmigrationspinal cord injurystem cell niche dynamicsstem cell transplantation

Identifiers

PMID28479305
PMCPMC5469937

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.