ArticleBehavioural brain research2017
Novel rodent model of breast cancer survival with persistent anxiety-like behavior and inflammation.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- The Significance of CXCL1 in Cancer: An Overview of Molecular Mechanisms.International journal of molecular sciences · 2026Review
- The role of microglia in 67NR mammary tumor-induced suppression of brain responses to immune challenges in female mice.Journal of neurochemistry · 2024Article
- Microglia contribute to mammary tumor-induced neuroinflammation in a female mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Surgical Primary Tumor Resection Reduces Accumulation of CD11bPharmaceuticals (Basel, Switzerland) · 2023Article
- Ovarian status modulates endocrine and neuroinflammatory responses to a murine mammary tumor.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Mammary tumors alter the fecal bacteriome and permit enteric bacterial translocation.BMC cancer · 2022Article
- A novel targeted approach to delineate a role for estrogen receptor-β in ameliorating murine mammary tumor-associated neuroinflammation.Endocrine · 2022Article
- Paclitaxel Chemotherapy Elicits Widespread Brain Anisotropy Changes in a Comprehensive Mouse Model of Breast Cancer Survivorship: Evidence FromFrontiers in oncology · 2022Article
- Chemotherapy-induced cognitive impairment: focus on the intersection of oxidative stress and TNFα.Cellular and molecular life sciences : CMLS · 2021Review
- Artificial Light at Night Reduces Anxiety-like Behavior in Female Mice with Exacerbated Mammary Tumor Growth.Cancers · 2021Article
- Tumor-Induced Cardiac Dysfunction: A Potential Role of ROS.Antioxidants (Basel, Switzerland) · 2021Article
- Manipulations of the gut microbiome alter chemotherapy-induced inflammation and behavioral side effects in female mice.Brain, behavior, and immunity · 2021Article
- Cognitive complications of cancer and cancer-related treatments - Novel paradigms.Neuroscience letters · 2021Review
- Targeting Myeloid-Derived Suppressor Cells Derived From Surgical Stress: The Key to Prevent Post-surgical Metastasis.Frontiers in surgery · 2021Article
- Psychosocial Stress and Age Influence Depression and Anxiety-Related Behavior, Drive Tumor Inflammatory Cytokines and Accelerate Prostate Cancer Growth in Mice.Frontiers in oncology · 2021Article
- Review
- Chemotherapy-induced neuroinflammation is associated with disrupted colonic and bacterial homeostasis in female mice.Scientific reports · 2019Article
- Mammary tumors compromise time-of-day differences in hypothalamic gene expression and circadian behavior and physiology in mice.Brain, behavior, and immunity · 2019Article
- Cancer and cancer survival modulates brain and behavior in a time-of-day-dependent manner in mice.Scientific reports · 2019Article
- Mammary tumor and mastectomy synergistically promote neuroinflammation in a breast cancer survivor model.Brain research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Breast cancer survivors are an expanding population that is troubled by lasting mental health problems, including depression and anxiety. These issues reduce quality-of-life throughout survivorhood. Research indicates that tumor biology, cancer treatments, and stress contribute to these mood disturbances. Although the mechanisms underlying these various causes remain under investigation, neuroinflammation is a leading hypothesis. To date, rodent models of recurrence-free tumor survival for understanding mechanisms by which these behavioral issues persist after cancer are lacking. Here, we test the extent to which potential behavioral symptoms persist after mammary tumor removal in mice (i.e., establishment of a cancer survivor model), while also empirically testing the causal role of tumors in the development of neuroinflammatory-mediated affective-like behaviors. Complete surgical resection of a non-metastatic orthotopic, syngeneic mammary tumor reversed tumor-induced increases of circulating cytokines (IL-6, CXCL1, IL-10) and myeloid-derived cells and modulated neuroinflammatory gene expression (Cd11b, Cxcl1). Multiple anxiety-like behaviors and some central and peripheral immune markers persisted or progressed three weeks after tumor resection. Together, these data indicate that persistent behavioral changes into cancer survivorhood may be due, in part, to changes in immunity that remain even after successful tumor removal. This novel survivor paradigm represents an improvement in modeling prevalent cancer survivorship issues and studying the basic mechanisms by which cancer/cancer treatments influence the brain and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.