ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017
Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- Trial
- Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression.Scientific reports · 2021Trial
- Cognitive control training as an add-on treatment for late-life depression: A multicenter randomized controlled trial.Internet interventions · 2026Article
- Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Accelerated Cognitive Decline in Late Life Depression: The Role of Amyloid-β, Cortico-Limbic Volume, and White Matter Hyperintensities.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Experiences and Perceptions of Functional Recovery in Late-Life Depression: A Qualitative Study.International journal of mental health nursing · 2025Article
- Abnormal functional network connectivity mediates the relationship between depressive symptoms and cognitive decline in late-onset depression.Psychological medicine · 2025Article
- Effects of Persistent Depression on Recall Memory are Moderated by Subjective Age Levels: Evidence From Community-Dwelling Older Adults.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Brain Age Is Not a Significant Predictor of Relapse Risk in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Depression and Anxiety in Older Adults: A Comparison Between Online Convenience and Conventional Representative Sampling.Depression and anxiety · 2025Article
- Healthy lifestyle behaviors and depressive symptoms: a national cross-sectional study of the older adults in China.Frontiers in medicine · 2025Article
- Reconsidering remission in recurrent late-life depression: clinical presentation and phenotypic predictors of relapse following successful antidepressant treatment.Psychological medicine · 2024Article
- The Role of State Versus Trait Anxiety on Cognition in Older Adults With Major Depressive Disorder.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Observational
- Relationship between Pain and Dementia: The Mediating Effect of Depression among Chinese Elderly.Actas espanolas de psiquiatria · 2024Article
- Assessing depression recurrence, cognitive burden, and neurobiological homeostasis in late life: Design and rationale of the REMBRANDT Study.Journal of mood and anxiety disorders · 2024Article
- Early depressive manifestations in patients with dementia caused by Alzheimer's disease.Experimental and therapeutic medicine · 2024Article
- Exploring the Reciprocal Relationship between Depressive Symptoms and Cognitive Function among Chinese Older Adults.Healthcare (Basel, Switzerland) · 2023Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveLate-life depression is associated with cognitive deficits and increased risk for cognitive decline. The purpose of the study was to determine whether clinical characteristics could serve as phenotypes informative of subsequent cognitive decline. Age at depression onset and antidepressant remission at 3 months (acute response) and 12 months (chronic response) were examined.
methodsIn a longitudinal study of late-life depression in an academic center, 273 depressed and 164 never-depressed community-dwelling elders aged 60 years or older were followed on average for over 5 years. Participants completed annual neuropsychological testing. Neuropsychological measures were converted to z-scores derived from the baseline performance of all participants. Cognitive domain scores at each time were then created by averaging z-scores across tests, grouped into domains of episodic memory, attention-working memory, verbal fluency, and executive function.
resultsDepressed participants exhibited poorer performance at baseline and greater subsequent decline in all domains. Early-onset depressed individuals exhibited a greater decline in all domains than late-onset or nondepressed groups. For remission, remitters and nonremitters at both 3 and 12 month exhibited greater decline in episodic memory and attention-working memory than nondepressed subjects. Three-month remitters also exhibited a greater decline in verbal fluency and executive function, whereas 12-month nonremitters exhibited greater decline in executive function than other groups.
conclusionConsistent with past studies, depressed elders exhibit greater cognitive decline than nondepressed subjects, particularly individuals with early depression onset, supporting the theory that repeated depressive episodes may contribute to decline. Clinical remission is not associated with less cognitive decline.
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