Evidence map›Paper›PMID 28479142›Full record

ReviewBiological psychology2018

Role of addiction and stress neurobiology on food intake and obesity.

Rajita Sinha

Abstract readReview
In one paragraph

Review in Biological psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 216 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  18. Review
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  20. The role of psychosocial well-being and emotion-driven impulsiveness in food choices of European adolescents.The international journal of behavioral nutrition and physical activity · 2024
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Rajita SinhaDepartment of Psychiatry, Yale University, School of Medicine, Yale Stress Center, 2 Church Street South, Suite 209, New Haven, CT 06519, United States; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, United States. Electronic address: rajita.sinha@yale.edu.
Yale University · US

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
GLP-1 analogue effects on food cues, stress, motivation for highly palatable foods, and weightR01DK099039 · NIDDK · YALE UNIVERSITY · PI JASTREBOFF, ANIA, SINHA, RAJITA · 2013 to 2024
$6.8M
Interdisciplinary Research on Stress, Self-Control & AddictionUL1DE019586 · NIDCR · YALE UNIVERSITY · PI SINHA, RAJITA · 2008 to 2011
$5.0M
Protocols, Statistics, Collaborative Method Development and ToolsPL1DA024859 · NIDA · YALE UNIVERSITY · PI SINHA, RAJITA · 2007 to 2011
$3.6M
Preventing Childhood Obesity Through a Mindfulness-based Parent Stress InterventionR01DK117651 · NIDDK · YALE UNIVERSITY · PI JASTREBOFF, ANIA, SILVERMAN, WENDY K. · 2018 to 2022
$3.5M
Preventing childhood obesity through a family-based mindfulness interventionR21AT007708 · NCCIH · YALE UNIVERSITY · PI SINHA, RAJITA · 2013 to 2014
$429k
NCCIH NIH HHS R21 AT007708NCRR NIH HHS UL1 RR024139NIDA NIH HHS PL1 DA024859NIDCR NIH HHS UL1 DE019586NIDDK NIH HHS R01 DK099039NIDDK NIH HHS R01 DK117651
6 · The paper itself

Abstract

The US remains at the forefront of a global obesity epidemic with a significant negative impact on public health. While it is well known that a balance between energy intake and expenditure is homeostatically regulated to control weight, growing evidence points to multifactorial social, neurobehavioral and metabolic determinants of food intake that influence obesity risk. This review presents factors such as the ubiquitous presence of rewarding foods in the environment and increased salience of such foods that stimulate brain reward motivation and stress circuits to influence eating behaviors. These rewarding foods via conditioned and reinforcing effects stimulate not only metabolic, but also stress hormones, that, in turn, hijack the brain emotional (limbic) and motivational (striatal) pathways, to promote food craving and excessive food intake. Furthermore, the impact of high levels of stress and trauma and altered metabolic environment (e.g. higher weight, altered insulin sensitivity) on prefrontal cortical self-control processes that regulate emotional, motivational and visceral homeostatic mechanisms of food intake and obesity risk are also discussed. A heuristic framework is presented in which the interactive dynamic effects of neurobehavioral adaptations in metabolic, motivation and stress neurobiology may further support food craving, excessive food intake and weight gain in a complex feed-forward manner. Implications of such adaptations in brain addictive-motivational and stress pathways and their effects on excessive food intake and weight gain are discussed to highlight key questions that requires future research attention in order to better understand and address the growing obesity epidemic.

Indexed as

CravingEatingEmotionsFeeding BehaviorFood AddictionHumansMotivationObesityRewardStress, PsychologicalWeight GainAddictionFood intakeNeurobiologyObesityStress

Identifiers

PMID28479142
PMCPMC6784832
OpenAlexW2610477874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.