ArticlePsychological medicine2017
Genetic and other risk factors for suicidal ideation and the relationship with depression.
Article in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterizing the phenomenology of passive suicidal ideation: a systematic review and meta-analysis of its prevalence, psychiatric comorbidity, correlates, and comparisons with active suicidal ideation.Psychological medicine · 2020Pooled it
- Rapid and sustained decreases in suicidality following a single dose of ayahuasca among individuals with recurrent major depressive disorder: results from an open-label trial.Psychopharmacology · 2021Trial
- Defining and assessing international classification of disease suicidality phenotypes for genetic studies.Psychiatry research · 2025Article
- Article
- Depressive Symptoms as a Mediator between Excessive Daytime Sleepiness and Suicidal Ideation among Chinese College Students.International journal of environmental research and public health · 2022Article
- Childhood trauma, life-time self-harm, and suicidal behaviour and ideation are associated with polygenic scores for autism.Molecular psychiatry · 2021Article
- Cognition in Recent Suicide Attempts: Altered Executive Function.Frontiers in psychiatry · 2021Article
- Effects of Health-Related Quality of Life on Suicidal Ideation and Depression among Older Korean Adults: A Cross-Sectional Study.Psychiatry investigation · 2021Article
- Depression, Non-Suicidal Self-Injury, and Suicidality in Adolescents: Common and Distinct Precursors, Correlates, and Outcomes.Journal of psychiatry and brain science · 2021Article
- Genetic aetiology of self-harm ideation and behaviour.Scientific reports · 2020Article
- Network analysis of the depressive symptom profiles in Asian patients with depressive disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD).Psychiatry and clinical neurosciences · 2020Article
- Predictors of Passive and Active Suicidal Ideation and Suicide Attempt Among Older People: A Study in Tertiary Care Settings in Thailand.Neuropsychiatric disease and treatment · 2020Article
- Post-Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation.Frontiers in psychiatry · 2020Article
- Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors.Psychological medicine · 2019Article
- The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial.Frontiers in pharmacology · 2019Article
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7 authors.
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Abstract
backgroundThere is a genetic contribution to the risk of suicide, but sparse prior research on the genetics of suicidal ideation.
methodsActive and passive suicidal ideation were assessed in a Sri Lankan population-based twin registry (n = 3906 twins) and a matched non-twin sample (n = 2016). Logistic regression models were used to examine associations with socio-demographic factors, environmental exposures and psychiatric symptoms. The heritability of suicidal ideation was assessed using structural equation modelling.
resultsThe lifetime prevalence of any suicidal ideation was 13.0% (11.7-14.3%) for men; 21.8% (20.3-23.2%) for women, with no significant difference between twins and non-twins. Factors that predicted suicidal ideation included female gender, termination of marital relationship, low education level, urban residence, losing a parent whilst young, low standard of living and stressful life events in the preceding 12 months. Suicidal ideation was strongly associated with depression, but also with abnormal fatigue and alcohol and tobacco use. The best fitting structural equation model indicated a substantial contribution from genetic factors (57%; CI 47-66) and from non-shared environmental factors (43%; CI 34-53) in both men and women. In women this genetic component was largely mediated through depression, but in men there was a significant heritable component to suicidal ideation that was independent of depression.
conclusionsThese are the first results to show a genetic contribution to suicidal ideation that is independent of depression outside of a high-income country. These phenomena may be generalizable, because previous research highlights similarities between the aetiology of mental disorders in Sri Lanka and higher-income countries.
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