Evidence map›Paper›PMID 28478776›Full record

ArticleEpidemiology and infection2017

An isolated outbreak of diphtheria in South Africa, 2015.

S Mahomed, M Archary, P Mutevedzi, Y Mahabeer, P Govender, G Ntshoe, W Kuhn, J Thomas, A Olowolagba, L Blumberg and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  14. Multidrug-resistant toxigenicMicrobial genomics · 2023
    Article
  15. Interactions between the Re-Emerging PathogenInternational journal of molecular sciences · 2022
    Review
  16. Article
  17. Respiratory Illness Caused by Corynebacterium diphtheriae and C. ulcerans, and Use of Diphtheria Antitoxin in the United States, 1996-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

S MahomedSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.ORCID http://orcid.org/0000-0001-7095-9186
M ArcharyKwaZulu-Natal Department of Health, Pietermaritzburg, South Africa.
P MutevedziKwaZulu-Natal Department of Health, Pietermaritzburg, South Africa.
Y MahabeerSchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
P GovenderKwaZulu-Natal Department of Health, Pietermaritzburg, South Africa.
G NtshoeNational Health Laboratory Service, Durban, South Africa.
W KuhnKwaZulu-Natal Department of Health, Pietermaritzburg, South Africa.
J ThomasNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
A OlowolagbaeThekwini Metropolitan Municipality Health Unit, Durban, South Africa.
L BlumbergNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
K McCarthyNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
K MlisanaNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
M DU PlessisNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
A VON GottbergNational Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
P MoodleySchool of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An outbreak of respiratory diphtheria occurred in two health districts in the province of KwaZulu-Natal in South Africa in 2015. A multidisciplinary outbreak response team was involved in the investigation and management of the outbreak. Fifteen cases of diphtheria were identified, with ages ranging from 4 to 41 years. Of the 12 cases that were under the age of 18 years, 9 (75%) were not fully immunized for diphtheria. The case fatality was 27%. Ninety-three household contacts, 981 school or work contacts and 595 healthcare worker contacts were identified and given prophylaxis against Corynebacterium diphtheriae infection. A targeted vaccination campaign for children aged 6-15 years was carried out at schools in the two districts. The outbreak highlighted the need to improve diphtheria vaccination coverage in the province and to investigate the feasibility of offering diphtheria vaccines to healthcare workers.

Indexed as

Disease OutbreaksAdolescentAdultChildChild, PreschoolCorynebacterium diphtheriaeDiphtheriaFemaleHumansImmunizationMaleRespiratory Tract InfectionsSouth AfricaYoung AdultDiphtheria antitoxinepidemiologysurveillancevaccine-preventable diseases

Identifiers

PMID28478776
PMCPMC9203423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.