Evidence map›Paper›PMID 28478586›Full record

ReviewCurrent hematologic malignancy reports2017

A Review of Autologous Stem Cell Transplantation in Lymphoma.

Umar Zahid, Faisal Akbar, Akshay Amaraneni, Muhammad Husnain, Onyee Chan, Irbaz Bin Riaz, Ali McBride, Ahmad Iftikhar, Faiz Anwer

Registry-linked trialAbstract readReview
In one paragraph

Review in Current hematologic malignancy reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06830031 (A Phase 1 Study of C402-CD19-CAR, a Chimeric Antigen Receptor T Cell), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06830031 phase1recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase 1 Study of C402-CD19-CAR, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Targeting CD19 in Subjects With Relapsed or Refractory Large B-cell Lymphoma

TypeinterventionalSponsorShanghai Exuma Biotechnology Ltd.Ran2025 to 2026Enrolled18ConditionsDiffuse Large B-cell-lymphoma, DLBCL, Nos Genetic Subtypes, Follicular Lymphoma Grade 3B, PMBLArmsC402-CD19-CAR
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Efficacy of the combination of umbilical fat and venous blood on limb salvage.Frontiers in bioengineering and biotechnology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Low Dose Cyclophospahamide is a Feasable Mobilization Regimen in the Covid-19 Era: A Single Center Study from Türkiye.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Article
  14. Article
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  16. Article
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  18. Review
  19. Article
  20. Sex-Based Differences in Risk of Therapy-Related Myeloid Neoplasms.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Umar ZahidDepartment of Medicine, University of Arizona, Tucson, AZ, USA.
Faisal AkbarDepartment of Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Akshay AmaraneniDepartment of Medicine, Hematology and Oncology, University of Arizona, Tucson, AZ, USA.
Muhammad HusnainInternal medicine Residency program, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Onyee ChanInternal medicine Residency program, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Irbaz Bin RiazDepartment of Medicine, University of Arizona, Tucson, AZ, USA.
Ali McBrideCollege of Pharmacy, University of Arizona, Tucson, AZ, USA.
Ahmad IftikharDepartment of Hematology and Oncology, University of Arizona, Tucson, AZ, USA.
Faiz AnwerDepartment of medicine, Hematology Oncology and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. anwerf@email.arizona.edu.
University of Arizona · USAtrium Health Wake Forest Baptist · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
NCI NIH HHS P30 CA023074
6 · The paper itself

Abstract

purpose of reviewChemotherapy remains the first-line therapy for aggressive lymphomas. However, 20-30% of patients with non-Hodgkin lymphoma (NHL) and 15% with Hodgkin lymphoma (HL) recur after initial therapy. We want to explore the role of high-dose chemotherapy (HDT) and autologous stem cell transplant (ASCT) for these patients. RECENT

findingsThere is some utility of upfront consolidation for-high risk/high-grade B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma, but there is no role of similar intervention for HL. New conditioning regimens are being investigated which have demonstrated an improved safety profile without compromising the myeloablative efficiency for relapsed or refractory HL. Salvage chemotherapy followed by HDT and rescue autologous stem cell transplant remains the standard of care for relapsed/refractory lymphoma. The role of novel agents to improve disease-related parameters remains to be elucidated in frontline induction, disease salvage, and high-dose consolidation or in the maintenance setting.

Indexed as

Hematopoietic Stem Cell TransplantationAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyConsolidation ChemotherapyDrug Resistance, NeoplasmHumansLymphomaMolecular Targeted TherapyRecurrenceRetreatmentSalvage TherapyTransplantation, AutologousTransplantation ConditioningTreatment OutcomeAutologous stem cell transplantationHigh-dose chemotherapyLymphomaNovel agentsRelapsed/refractorySalvage chemotherapy

Identifiers

PMID28478586
PMCPMC5607634
OpenAlexW2610467364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.