Evidence map›Paper›PMID 28478508›Full record

ArticleMolecular neurobiology2018

Deciphering the Biochemical Pathway and Pharmacokinetic Study of Amyloid βeta-42 with Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Using Systems Biology Approach.

Aman Chandra Kaushik, Ajay Kumar, Vivek Dhar Dwivedi, Shiv Bharadwaj, Sanjay Kumar, Kritika Bharti, Pavan Kumar, Ravi Kumar Chaudhary, Sarad Kumar Mishra

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Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  5. Designing of CD8Biologics : targets & therapy · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aman Chandra KaushikSchool of Biotechnology, Gautam Buddha University, Greater Noida, India.
Ajay KumarSchool of Engineering, Gautam Buddha University, Greater Noida, India.
Vivek Dhar DwivediFaculty of Science and Environment, Mahatma Gandhi Chitrakoot Rural University, Satna, Chitrakoot, India.
Shiv BharadwajNanotechnology Research and Application Center, Sabanci University, Istanbul, Turkey.
Sanjay KumarMolecular Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Kritika BhartiDepartment of Biotechnology, Jaypee Institute of Information Technology, Noida, UP, India.
Pavan KumarSchool of Biotechnology, Gautam Buddha University, Greater Noida, India.
Ravi Kumar ChaudharySchool of Biotechnology, Gautam Buddha University, Greater Noida, India. k.ravi7988@gmail.com.
Sarad Kumar MishraDepartment of Biotechnology, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur, India. mishrask2000@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) pathogenesis leads to the appearance of senile plaques due to the production and deposition of the β-amyloid peptide (Aβ). Superparamagnetic iron oxide nanoparticles (SPIONs) have potential role in the detection and imaging of Aβ plaques in AD. SPIONs have shown appropriate potential in the diagnosis and treatment of AD. In the present study, the pharmacokinetics of SPIONs and its effect in the biochemical pathway of AD were analyzed using collected information. During analysis, the interaction of SPIONs with amyloid beta-42 (Aβ

Indexed as

Signal TransductionSystems BiologyAlzheimer DiseaseAmyloid beta-PeptidesDextransGoldHumansMagnetite NanoparticlesMolecular Docking SimulationPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)DextransferumoxidesGoldMagnetite NanoparticlesPeptide FragmentsAlzheimer’s diseaseAmyloid beta-42Biochemical networkPharmacokineticsSPIONs

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.