ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2017
The impact on cognitive functions of patients with pituitary adenoma before and after surgery.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The impact of pituitary adenomas on cognitive performance: a systematic review.Frontiers in endocrinology · 2025Pooled it
- Pituitary adenomas and neuropsychological status: a systematic literature review.Neurosurgical review · 2020Pooled it
- Distinct gut microbial profile in PIT1 lineage PitNETs: a potential link to cognitive impairment.Chinese neurosurgical journal · 2025Article
- Article
- Cognitive function and fatigue before and after transsphenoidal surgery in patients with pituitary adenoma: a prospective study.Pituitary · 2025Article
- Impact of growth hormone-secreting pituitary adenoma on limbic system and its correlation with cognitive impairment.Heliyon · 2024Article
- Pituitary neuroendocrine tumor: A neuropsychological comparison with intra-axial tumor.Annals of clinical and translational neurology · 2024Article
- Article
- Research status and prospects of pituitary adenomas in conjunction with neurological and psychiatric disorders and the tumor microenvironment.Frontiers in neuroscience · 2024Review
- Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors: Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations.Neuroscience bulletin · 2023Review
- Identifying hormones and other perioperative risk factors for postoperative delirium after endoscope-assisted transsphenoidal pituitary adenoma resection: A retrospective, matched cohort study.Brain and behavior · 2023Article
- Cognitive Dysfunction, an Increasingly Valued Long-Term Impairment in Acromegaly.Journal of clinical medicine · 2023Review
- Brain Tumor at Diagnosis: From Cognition and Behavior to Quality of Life.Diagnostics (Basel, Switzerland) · 2023Review
- Glymphatic transport is reduced in rats with spontaneous pituitary tumor.Frontiers in medicine · 2023Article
- Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with Prolactinomas.Brain sciences · 2022Article
- Endoscopic vs. microscopic transsphenoidal surgery outcomes in 514 nonfunctioning pituitary adenoma cases.Neurosurgical review · 2022Article
- Improvement in Attention Processing After Surgical Treatment in Functional Pituitary Adenomas: Evidence From ERP Study.Frontiers in neurology · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Patients with pituitary adenoma have often suffered cognitive impairment. The study aims to identify the factors, and their impact, that affect the cognitive functions of pituitary adenoma patients. Seventy-six patients with pituitary adenoma were recruited, together with 76 healthy subjects as control. Patients (34 functioning and 42 non-functioning) were randomly assigned into either microscopic (n = 44) or neural endoscopic (n = 32) group. All surgeries were performed through single-nostril transsphenoidal approach under general anesthesia with endotracheal intubation. All patients were examined with cognitive assessments (CAMCOG-C and MMSE tests), tumor size, eyesight, and hormone levels before surgery. Three months after surgery, all patients were examined again to check hormone level changes by blood samples, tumor excision status via MRI, and cognitive assessments. Compared with healthy control, total score and multiple cognitive scores of CAMCOG-C and MMSE were significantly lower before surgery. There were no correlations between cognitive functions and tumor size or eyesight. Significant difference in cognitive functions was found between functioning and non-functioning pituitary adenoma patients. Significant increase in cognitive functions occurred after surgery, whereas no difference was detected between the two different surgical treatments. The hormone levels were improved significantly in patients with hormone disorders after surgery. The physical compression from tumor might not play a key role in cognitive impairment. However, hormone disorders could be a major factor to cognitive impairment. The improvement in cognitive functions is attributed to the amelioration of endocrine disorders. There were no differences between two surgical treatments.
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