SynthesisInternal and emergency medicine2017
Diagnostic accuracy of novel serological biomarkers to detect acute mesenteric ischemia: a systematic review and meta-analysis.
Synthesis in Internal and emergency medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2023Pooled it
- Diagnostic accuracy of novel serological biomarkers to detect acute mesenteric ischemia: a systematic review and meta-analysis.Internal and emergency medicine · 2017Pooled it
- Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial.Intensive care medicine · 2019Trial
- Intestinal fatty acid-binding protein (I-FABP) at ICU admission as early biomarker of intestinal injury and predictor of mortality in septic shock.Intensive care medicine experimental · 2026Article
- Current Evidence on the Management of Non-occlusive Mesenteric Ischemia: A Comprehensive Narrative Review.Cureus · 2026Review
- Representation and Utilization of Laboratory Data in CT-Based Acute Abdominal Emergency Radiology: A Methodological Content Analysis.Tomography (Ann Arbor, Mich.) · 2026Review
- Predicting In-Hospital Mortality in Acute Mesenteric Ischemia: The RADIAL Score.Journal of clinical medicine · 2026Article
- Integrated Radiology-Biochemistry Diagnostic Flow Framework for Emergency Clinical Decision Support: A Simulation-Based Educational Model.Tomography (Ann Arbor, Mich.) · 2026Article
- Plasma levels of intestinal fatty acid-binding protein and citrulline are not associated with severe upper gastrointestinal ischemic lesions after out-of-hospital cardiac arrest: an ancillary study of the ENTRACT trial.Resuscitation plus · 2026Article
- Diagnostic utility of inflammatory ratios and nutritional scores in acute mesenteric ischemia: A retrospective single-center study.Turkish journal of surgery · 2025Article
- Visceral Arterial Pseudoaneurysms-A Clinical Review.Medicina (Kaunas, Lithuania) · 2025Review
- Longitudinal analysis of serum intestinal fatty acid-binding protein in a patient with non-occlusive mesenteric ischemia following brachial plexus block-induced hypotension: a case study.Clinical journal of gastroenterology · 2025Article
- Extracellular matrix gene set and microRNA network in intestinal ischemia-reperfusion injury: Insights from RNA sequencing for diagnosis and therapy.World journal of gastrointestinal surgery · 2025Review
- A review of gut failure as a cause and consequence of critical illness.Critical care (London, England) · 2025Review
- Tricky acute mesenteric ischemia: what can we do?Gastroenterology report · 2025Review
- Effective new predictors of prognosis and comparison of multidisciplinary treatment options in acute mesenteric ischemia.Northern clinics of Istanbul · 2025Article
- Intestinal fatty acid-binding protein (I-FABP) as biomarker of ischemic damage in experimentally induced 12-h small bowel obstruction.Updates in surgery · 2024Article
- Association between periodic variation of air temperature, humidity, atmospheric pressure and hospital admissions for acute occlusive mesenteric ischaemia.Scientific reports · 2024Article
- Enteric fungi protect against intestinal ischemia-reperfusion injury via inhibiting the SAA1-GSDMD pathway.Journal of advanced research · 2024Article
- Diagnostic Role of Multi-Detector Computed Tomography in Acute Mesenteric Ischemia.Diagnostics (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laparotomy remains the gold standard for diagnosis of acute mesenteric ischemia (AMI), but is often unhelpful or too late due to non-specific clinical and radiological signs. This systematic review and meta-analysis aims to evaluate the diagnostic accuracy of the novel serological biomarkers intestinal fatty acid-binding protein (I-FABP), α-glutathione S-transferase (α-GST), D-lactate, ischemia modified albumin (IMA), and citrulline to detect AMI. A systematic search of electronic databases was performed to identify all published diagnostic accuracy studies on I-FABP, α-GST, D-lactate, IMA, and citrulline. Articles were selected based on pre-defined inclusion and exclusion criteria. Risk of bias and applicability were assessed. Two-by-two contingency tables were constructed to calculate accuracy standards. Summary estimates were computed using random-effects models. The search yielded 1925 papers, 21 were included in the final analysis. Pooled sensitivity and specificity for investigated biomarkers were: I-FABP (Uden); 79.0 (95% CI 66.5-88.5) and 91.3 (87.0-94.6), I-FABP (Osaka); 75.0 (67.9-81.2) and 79.2 (76.2-82.0), D-lactate; 71.7 (58.6-82.5) and 74.2 (69.0-79.0), α-GST; 67.8 (54.2-79.5) and 84.2 (75.3-90.9), IMA; 94.7 (74.0-99.9) and 86.4 (65.1-97.1), respectively. One study investigated accuracy standards for citrulline: sensitivity 39% and specificity 100%. The novel serological biomarkers I-FABP, α-GST, IMA, and citrulline may offer improved diagnostic accuracy of acute mesenteric ischemia; however, further research is required to specify threshold values and accuracy standards for different aetiological forms.
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