Evidence map›Paper›PMID 28478386›Full record

ArticleBMJ case reports2017

Fever without a source: evolution of a diagnosis from Kawasaki disease to acute myelogenous leukaemia.

Begem Lee, Christine D Kofman, Adriana H Tremoulet, Dennis John Kuo

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Begem LeeDepartment of Pediatrics, University of California, San Diego, San Diego, California, USA.
Christine D KofmanDepartment of Pediatrics, University of California, San Diego, San Diego, California, USA.
Adriana H TremouletDepartment of Pediatrics, University of California, San Diego, San Diego, California, USA.
Dennis John KuoDivision of Pediatric Hematology-Oncology, University of California, San Diego, San Diego, California, USA.ORCID http://orcid.org/0000-0003-4154-0057
University of California San Diego · USUniversity of San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A previously healthy 11-month-old male patient presented with fever, abdominal pain and irritability. As part of an extensive evaluation for the cause of his fevers, an echocardiogram was performed and showed mildly dilated coronary arteries, leading to a diagnosis of incomplete Kawasaki disease (KD). He was treated with intravenous immunoglobulin (IVIG), defervesced and was discharged home. Two weeks later, he presented with anaemia initially attributed to haemolytic anaemia secondary to IVIG and received a red blood cell transfusion. However, his anaemia recurred 2  weeks later with leucocytosis, prompting a bone marrow aspirate 4  weeks after his diagnosis of KD. This demonstrated acute myelogenous leukaemia most consistent with acute megakaryocytic leukaemia. This case highlights the potentially subtle presentation of acute leukaemia and the need to keep an open mind and reconsider the initial diagnosis as new information comes to light in the care of an ill child.

Indexed as

AftercareAnemiaBone Marrow ExaminationEchocardiographyErythrocyte TransfusionFeverHematopoietic Stem Cell TransplantationHumansImmunoglobulins, IntravenousInfantLeukemia, Myeloid, AcuteMaleMucocutaneous Lymph Node SyndromeTreatment OutcomeImmunoglobulins, IntravenousCardiovascular medicinePaediatric oncology

Identifiers

PMID28478386
PMCPMC5612012
OpenAlexW2611706740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.