Trial reportJournal of the neurological sciences2017
Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort.
Trial report in Journal of the neurological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of boxing exercise in people with Parkinson's disease: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Interventions for preventing falls in Parkinson's disease.The Cochrane database of systematic reviews · 2022Pooled it
- A machine learning approach to quantifying fall conversion risk in fall-naïve Parkinson's patients.Parkinsonism & related disorders · 2026Article
- Sex Differences in Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross-Sectional Analysis.Movement disorders clinical practice · 2026Article
- Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross-Sectional Analysis.medRxiv : the preprint server for health sciences · 2025Article
- Cognitive measures predict falls in Parkinson's disease: Insights from the CYCLE-II cohort.Parkinsonism & related disorders · 2025Article
- Predicting Ambulatory Capacity in Parkinson's Disease to Analyze Progression, Biomarkers, and Trial Design.Movement disorders : official journal of the Movement Disorder Society · 2023Observational
- Efficacy of Dual-Task Training in Patients with Parkinson's Disease: A Systematic Review with Meta-Analysis.Movement disorders clinical practice · 2023Review
- Longitudinal Cohort Study of Verbatim-Reported Postural Instability Symptoms as Outcomes for Online Parkinson's Disease Trials.Journal of Parkinson's disease · 2022Observational
- Association of fall risk factors and non-motor symptoms in patients with early Parkinson's disease.Scientific reports · 2021Article
- Better quality of life and less caregiver strain in young-onset Parkinson's disease: a multicentre retrospective cohort study.Journal of neurology · 2021Article
- Predictive Value of Verbatim Parkinson's Disease Patient-Reported Symptoms of Postural Instability and Falling.Journal of Parkinson's disease · 2021Article
- Risk Factors for Falls in Patients with de novo Parkinson's Disease: A Focus on Motor and Non-Motor Symptoms.Journal of movement disorders · 2020Article
- Lower Limb Rigidity Is Associated with Frequent Falls in Parkinson's Disease.Movement disorders clinical practice · 2019Article
- Cardiovascular autonomic neuropathy and falls in Parkinson disease: a prospective cohort study.Journal of neurology · 2019Article
- Romberg ratio coefficient in quiet stance and postural control in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- What predicts falls in Parkinson disease?: Observations from the Parkinson's Foundation registry.Neurology. Clinical practice · 2018Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
backgroundRecognizing the factors associated with falling in Parkinson's disease (PD) would improve identification of at-risk individuals.
objectiveTo examine frequency of falling and baseline characteristics associated with falling in PD using the National Institute of Neurological Disorders and Stroke (NINDS) Exploratory Trials in PD Long-term Study-1 (NET-PD LS-1) dataset.
methodsThe LS-1 database included 1741 early treated PD subjects (median 4year follow-up). Baseline characteristics were tested for a univariate association with post-baseline falling during the trial. Significant variables were included in a multivariable logistic regression model. A separate analysis using a negative binomial model investigated baseline factors on fall rate.
results728 subjects (42%) fell during the trial, including at baseline. A baseline history of falls was the factor most associated with post-baseline falling. Men had lower odds of post-baseline falling compared to women, but for men, the probability of a post-baseline fall increased with age such that after age 70, men and women had similar odds of falling. Other baseline factors associated with a post-baseline fall and increased fall rate included the Unified PD Rating Scale (UPDRS) Activities of Daily Living (ADL) score, total functional capacity (TFC), baseline ambulatory capacity score and dopamine agonist monotherapy.
conclusionFalls are common in early treated PD. The biggest risk factor for falls in PD remains a history of falling. Measures of functional ability (UPDRS ADL, TFC) and ambulatory capacity are novel clinical risk factors needing further study. A significant age by sex interaction may help to explain why age has been an inconsistent risk factor for falls in PD.
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