ArticleBMC microbiology2017
In vitro and in vivo antagonistic activity of new probiotic culture against Clostridium difficile and Clostridium perfringens.
Article in BMC microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Antioxidant Potential of Probiotics and Postbiotics Derived from Lactic Acid Bacteria and Their Impact on Foods.Foods (Basel, Switzerland) · 2026Review
- Oral administration of the probiotic strainFrontiers in pharmacology · 2025Article
- Insight into the Probiogenomic Potential ofFoods (Basel, Switzerland) · 2024Article
- Probiotics for Prevention and Treatment of Clostridium difficile Infection.Advances in experimental medicine and biology · 2024Article
- Reduction of Pathogens in Feces and Lymph Nodes Collected from Beef Cattle FedFoods (Basel, Switzerland) · 2022Article
- Article
- Protective Effects of NovelMicroorganisms · 2022Article
- Combination of Natural Compounds With Novel Non-thermal Technologies for Poultry Products: A Review.Frontiers in nutrition · 2021Review
- Yogurt Produced by Novel Natural Starter Cultures Improves Gut Epithelial Barrier In Vitro.Microorganisms · 2020Article
- Research Note: Effect of synbiotic supplementation on caecal Clostridium perfringens load in broiler chickens with different necrotic enteritis challenge models.Poultry science · 2020Article
- Influence of Pichia pastoris X-33 produced in industrial residues on productive performance, egg quality, immunity, and intestinal morphometry in quails.Scientific reports · 2019Article
- Probiotics and Clostridium Difficile: A Review of Dysbiosis and the Rehabilitation of Gut Microbiota.Cureus · 2019Review
- In Vitro Antimicrobial Activity and Probiotic Potential ofNutrients · 2019Article
- Antibacterial Activity ofFrontiers in cellular and infection microbiology · 2019Article
- Food-Origin Lactic Acid Bacteria May Exhibit Probiotic Properties: Review.BioMed research international · 2018Review
- Effect ofFrontiers in microbiology · 2018Article
- Promotion of Early Gut Colonization by Probiotic Intervention on Microbiota Diversity in Pregnant Sows.Frontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenus Clostridium accompanies more than 200 known species and at least 30 among them are associated with human and animal diseases. At the moment, the treatment of clostridial infections is based on use of antibiotics. However, due to the European ban on the use of antibiotics in livestock production, novel therapeutic strategies for treatment of these hardly curable infections have been evaluated. Hence, in this study the antimicrobial effect of newly designed probiotic culture consisted of natural isolates Lactobacillus helveticus BGRA43, Lactobacillus fermentum BGHI14 and Streptococcus thermophilus BGVLJ1-44 against Clostridium difficile and Clostridium perfringens was analyzed.
resultsThe probiotic culture showed strong in vitro antimicrobial effect on C. difficile (human clinical isolate). In addition, individual strains and the probiotic combination exhibited immunomodulatory activity. The probiotic combination significantly increased the proliferation of GALT lymphocytes. At the other hand, none of the bacterial treatments (individual strains and the combination) induced the production of proinflammatory cytokines IL-6 and IL-1β by intestinal epithelial cells, Caco-2. Interestingly, Caco-2 cells exposed to the probiotic combination produced significantly elevated amount of TGFβ pointing to potential protecting effect of the probiotic. In addition, the results of field trial on spontaneously infected goats revealed reduction of C. perfringens in goats (below the detection threshold) after the probiotic treatment.
conclusionsThe results of this study indicated that the novel probiotic deserves to be further investigated as a promising antimicrobial agent against C. difficile and C. perfringens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.