Evidence map›Paper›PMID 28477329›Full record

Observational studyIrish journal of medical science2017

Is chemotherapy always required for cancer in pregnancy? An observational study.

E M Walsh, G M O'Kane, K A Cadoo, D M Graham, G J Korpanty, D G Power, D N Carney

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Irish journal of medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Treatment of Early Stages Hodgkin Lymphoma During Pregnancy.Mediterranean journal of hematology and infectious diseases · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

E M WalshDepartment of Medical Oncology, Mater Misericordiae University Hospital, Dublin, Ireland. elaine1walsh@gmail.com.
G M O'KaneDepartment of Medical Oncology, Mater Misericordiae University Hospital, Dublin, Ireland.
K A CadooDepartment of Medical Oncology, Mater Misericordiae University Hospital, Dublin, Ireland.
D M GrahamDepartment of Medical Oncology, Mater Misericordiae University Hospital, Dublin, Ireland.
G J KorpantyDepartment of Medical Oncology, Mater Misericordiae University Hospital, Dublin, Ireland.
D G PowerDepartment of Medical Oncology, Cork University Hospital and Mercy University Hospital, Cork, Ireland.
D N CarneyDepartment of Medical Oncology, Mater Misericordiae University Hospital, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer in pregnancy is relatively rare, but the incidence is increasing. Several studies show that cytotoxic agents are safe to use in pregnancy from the second trimester onwards.

aimsThis study assesses the maternal and foetal outcomes of cancers diagnosed during pregnancy. In particular, it focuses on a subset of women who elected to defer systemic chemotherapy until after delivery. This study examines if all cancers need to be treated during pregnancy or if, in certain cases, treatment can be safely deferred until after full-term delivery.

methodsThis is a retrospective observational study of women diagnosed with cancer during pregnancy in an Irish cancer centre over a 27-year period. All women diagnosed with cancer during pregnancy who were referred to the medical oncology department for consideration of chemotherapy were included in this study. Medical and pharmacy records were extensively reviewed.

resultsTwenty-five women were diagnosed with cancer in pregnancy and referred to medical oncology for consideration of systemic chemotherapy. Sixteen women (64%) commenced chemotherapy during pregnancy, seven women (28%) did not receive chemotherapy while pregnant, but commenced treatment immediately after delivery, and two (8%) did not receive any systemic chemotherapy at all. Of the seven women who commenced chemotherapy after delivery, six (85.7%) were diagnosed before 30/40 gestation. There were three cases of Hodgkin's lymphoma, two breast cancers and one ovarian cancer. After a median follow-up of 12 years, all six mothers remain disease-free.

conclusionsThis study identified a select cohort of patients that did not receive chemotherapy during pregnancy. There were no adverse outcomes to mothers due to delayed treatment.

Indexed as

AdultDrug TherapyFemaleHumansPregnancyPregnancy Complications, NeoplasticPregnancy OutcomeRetrospective StudiesYoung AdultCancerCancer in pregnancyChemotherapyOutcomesPregnancyPregnancy-associated cancer

Identifiers

PMID28477329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.