Evidence map›Paper›PMID 28477151›Full record

Observational studyNeurocritical care2017

Coagulation Testing in Intracerebral Hemorrhage Related to Non-vitamin K Antagonist Oral Anticoagulants.

Jan C Purrucker, Timolaos Rizos, Kirsten Haas, Marcel Wolf, Shujah Khan, Peter U Heuschmann, Roland Veltkamp, RASUNOA investigators

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurocritical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Management of Spontaneous Intracerebral Hemorrhage.Current neurology and neuroscience reports · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jan C PurruckerDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Timolaos RizosDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Kirsten HaasInstitute of Clinical Epidemiology and Biometry, University Würzburg, Würzburg, Germany.
Marcel WolfDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Shujah KhanDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Peter U HeuschmannInstitute of Clinical Epidemiology and Biometry, University Würzburg, Würzburg, Germany.
Roland VeltkampDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany. r.veltkamp@imperial.ac.uk.
RASUNOA investigators
Heidelberg University · DECharing Cross Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntracerebral hemorrhage (ICH) is a life-threatening complication of non-vitamin K antagonist oral anticoagulants (NOAC). Little is known about the effect of intensity of anticoagulation on NOAC-ICH. We describe the current use of coagulation testing in the emergency setting and explore associations with baseline size and expansion of hematoma as determined in a previous study.

methodsData from the prospective multicenter RASUNOA registry were analyzed. Patients with NOAC-ICH were enrolled between February 2012 and December 2014. Frequency of local test performance of specific (anti-factor Xa tests, diluted thrombin time) and non-specific tests (international normalized ratio (INR), activated partial thromboplastin time (aPTT), thrombin time) was analyzed. The association of anticoagulation intensity at admission with hematoma volume and hematoma expansion was explored.

resultsIn 61 NOAC-ICH patients enrolled at 21 centers, drug-specific coagulation testing was performed in 16 cases (26%), and only 29% of centers appeared to use drug-specific tests in NOAC-ICH at all. In some cases, INR and aPTT values were normal despite drug concentrations in the peak range. In patients with available drug-specific concentrations, 50% had drug levels in the peak range at admission. Higher intensity of anticoagulation was not associated with higher hematoma volume at admission or with subsequent hematoma expansion.

conclusionDrug-specific tests are only infrequently used in NOAC-ICH. Normal results in non-specific coagulation do not reliably rule out peak range concentrations. Anticoagulation intensity at admission does not predict baseline hematoma volume or subsequent hematoma expansion.

Indexed as

RegistriesAgedAged, 80 and overAntithrombinsBlood Coagulation TestsCerebral HemorrhageFemaleHumansMaleMiddle AgedStrokeVitamin KAntithrombinsVitamin KAnticoagulationIntracerebral hemorrhageLaboratory testingOral anticoagulantsStroke

Identifiers

PMID28477151
OpenAlexW2611545394

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.