Evidence map›Paper›PMID 28477098›Full record

ArticleHeart and vessels2017

Predictors of thrombus formation after percutaneous left atrial appendage closure using the WATCHMAN device.

Hidehiro Kaneko, Michael Neuss, Jens Weissenborn, Christian Butter

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03539055 (Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03539055 phase4completednot on this mapstarted 2018, after this paper: background citation

Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA (Left Atrial Appendage) Device Closure (the DEA-LAA Study).

TypeinterventionalSponsorVanderbilt University Medical CenterRan2018 to 2024Enrolled100ConditionsAtrial Fibrillation, Device Related Thrombus, Left Atrial Appendage Thrombosis, Watchman LAA Closure DeviceArmsDabigatran Etexilate Oral Capsule
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Device-Related Thrombosis in Patients Receiving One-Stop Intervention for Nonvalvular Atrial Fibrillation: A Systemic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  2. Article
  3. Observational
  4. Article
  5. A comparison of simplified or conventional antithrombotic regimens after left atrial appendage closure in patients at high bleeding risk: the PLATEBRISK study.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Women and atrial fibrillation.Journal of cardiovascular electrophysiology · 2021
    Review
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  12. Review
  13. Article
  14. Article
  15. Review
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hidehiro KanekoDepartment of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321, Bernau, Germany.
Michael NeussDepartment of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321, Bernau, Germany.
Jens WeissenbornDepartment of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321, Bernau, Germany.
Christian ButterDepartment of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321, Bernau, Germany. c.butter@immanuel.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Percutaneous left atrial appendage (LAA) closure using the WATCHMAN device is a novel option for prevention of stroke associated with atrial fibrillation. However, device-related thrombus (DRT) formation is a concern after WATCHMAN implantation and the predictors of DRT still remain unclear. We aimed to clarify the predictors of DRT after WATCHMAN implantation by analyzing 78 patients (50 males, 72 ± 8 years, average CHA2DS2-VASc score of 4.3 + 1.8) who had undergone WATCHMAN implantation. WATCHMAN was successfully implanted in all patients and four (5%) developed DRT. Patients with DRT were more often female (75 vs. 34%, p = 0.094). CHA2DS2-VASc score was higher for patients with DRT (6.3 ± 2.5 vs. 4.2 ± 1.7, p = 0.022). Chronic kidney disease (100% vs. 43%, p = 0.024) and deep implantation of the device, which was defined as implant position below the LAA ostial plane (75 vs. 24%, p = 0.026), were more common in patients with DRT. HAS-BLED score (4.5 ± 1.0 vs. 3.5 ± 1.1, p = 0.074) was higher and oral anticoagulants (50 vs. 84%, p = 0.086) were less commonly prescribed for patients with DRT. Multivariable logistic regression analysis showed that higher CHA2DS2-VASc score (p = 0.022, OR 2.8) and deep implantation (p = 0.032, OR 24.7) were associated with DRT. These results suggest the possible role of CHA2S2-VASc scores and implantation depth in the development of DRT after percutaneous LAA closure using the WATCHMAN device.

Indexed as

Septal Occluder DeviceAgedAtrial AppendageAtrial FibrillationCardiac Surgical ProceduresFemaleHumansMalePostoperative ComplicationsProsthesis DesignStrokeThrombosisTreatment OutcomeAtrial fibrillationCHA2DS2-VASc scoreImplantation depthLeft atrial appendage closureThrombusWATCHMAN

Identifiers

PMID28477098

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.