ArticleIET systems biology2017
Excluded volume effects in on- and off-lattice reaction-diffusion models.
Article in IET systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Interkinetic nuclear movements promote apical expansion in pseudostratified epithelia at the expense of apicobasal elongation.PLoS computational biology · 2019Article
- Multiscale Modeling of Diffusion in a Crowded Environment.Bulletin of mathematical biology · 2017Article
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2 authors.
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Abstract
Mathematical models are important tools to study the excluded volume effects on reaction-diffusion systems, which are known to play an important role inside living cells. Detailed microscopic simulations with off-lattice Brownian dynamics become computationally expensive in crowded environments. In this study, the authors therefore investigate to which extent on-lattice approximations, the so-called cellular automata models, can be used to simulate reactions and diffusion in the presence of crowding molecules. They show that the diffusion is most severely slowed down in the off-lattice model, since randomly distributed obstacles effectively exclude more volume than those ordered on an artificial grid. Crowded reaction rates can be both increased and decreased by the grid structure and it proves important to model the molecules with realistic sizes when excluded volume is taken into account. The grid artefacts increase with increasing crowder density and they conclude that the computationally more efficient on-lattice simulations are accurate approximations only for low crowder densities.
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