ArticleDiabetes2017
A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in
Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians.International journal of obesity (2005) · 2023Pooled it
- Pooled it
- Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.Gastroenterology · 2019Pooled it
- Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes.Nature metabolism · 2026Article
- Neurobehavioural genes exert indirect genetic effects on blood lipid profiles through behavioural traits.Communications biology · 2026Article
- Pleiotropic Effects of an eQTL in the CELSR2/PSRC1/SORT1 Cluster That Associates With LDL-C and Resting Metabolic Rate.The Journal of clinical endocrinology and metabolism · 2025Article
- Article
- Epistasis Between HLA-DRB1*16:02:01 and SLC16A11 T-C-G-T-T Reduces Odds for Type 2 Diabetes in Southwest American Indians.Diabetes · 2024Article
- Novel signals and polygenic score for height are associated with pubertal growth traits in Southwestern American Indians.Human molecular genetics · 2024Article
- Determinants of obesity in Latin America.Nature metabolism · 2024 · on this mapReview
- Transcriptional profiles analysis of effects ofFrontiers in cellular and infection microbiology · 2024Article
- Effects of theBMJ open diabetes research & care · 2023Article
- Review
- Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Observational
- The counterbalancing effects of energy expenditure on body weight regulation: Orexigenic versus energy-consuming mechanisms.Obesity (Silver Spring, Md.) · 2022Article
- Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity.Obesity (Silver Spring, Md.) · 2022Article
- The emerging roles of GPR158 in the regulation of the endocrine system.Frontiers in cell and developmental biology · 2022Review
- Exome Sequencing Identifies A Nonsense Variant in DAO Associated With Reduced Energy Expenditure in American Indians.The Journal of clinical endocrinology and metabolism · 2020Article
- Early adaptive thermogenesis is a determinant of weight loss after six weeks of caloric restriction in overweight subjects.Metabolism: clinical and experimental · 2020Article
- An appraisal of whole-room indirect calorimeters and a metabolic cart for measuring resting and active metabolic rates.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 3 countries.
Funding
Abstract
Pima Indians living in Arizona have a high prevalence of obesity, and we have previously shown that a relatively lower energy expenditure (EE) predicts weight and fat mass gain in this population. EE is a familial trait (heritability = 0.52); therefore, in the current study, we aimed to identify genetic variants that affect EE and thereby influence BMI and body fatness in Pima Indians. Genotypic data from 491,265 variants were analyzed for association with resting metabolic rate (RMR) and 24-h EE assessed in a whole-room calorimeter in 507 and 419 Pima Indians, respectively. Variants associated with both measures of EE were analyzed for association with maximum BMI and percent body fat (PFAT) in 5,870 and 912 Pima Indians, respectively. rs11014566 nominally associated with both measures of EE and both measures of adiposity in Pima Indians, where the G allele (frequency: Pima Indians = 0.60, Europeans <0.01) associated with lower 24-h EE (β = -33 kcal/day per copy), lower RMR (β = -31 kcal/day), higher BMI (β = +0.6 kg/m
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.