ArticleThe Journal of biological chemistry2017
Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
39 citing papers in PubMed, 61 citations in OpenAlex.
- Clustering Properties of Neuronal Ryanodine Receptor 2 and Remodeling in the APP/PS1 Mouse Model of Alzheimer's Disease.Acta physiologica (Oxford, England) · 2026Article
- Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation.Nature communications · 2026Article
- Gene-Exercise Interactions in Amyloid Metabolism and Clearance: Implications for Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Targeting the serotonergic system in the treatment of neurodegenerative diseases-emerging therapies and unmet challenges.Pharmacological reviews · 2025Review
- Review
- Implication of Central βArchiv der Pharmazie · 2025Review
- Deciphering the Role of Adrenergic Receptors in Alzheimer's Disease: Paving the Way for Innovative Therapies.Biomolecules · 2025Review
- The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.Cell death & disease · 2024Article
- Calcium Dyshomeostasis Drives Pathophysiology and Neuronal Demise in Age-Related Neurodegenerative Diseases.International journal of molecular sciences · 2023Review
- Heart failure-induced cognitive dysfunction is mediated by intracellular CaNature neuroscience · 2023Article
- Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer's disease.IBRO neuroscience reports · 2023Article
- Review
- Targeting ryanodine receptors to treat human diseases.The Journal of clinical investigation · 2023Review
- Novel Algorithm of Network Calcium Dynamics Analysis for Studying the Role of Astrocytes in Neuronal Activity in Alzheimer's Disease Models.International journal of molecular sciences · 2022Article
- Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer's Disease and Lewy Body Dementia.Biomedicines · 2022Article
- Inhibiting Calcium Release from Ryanodine Receptors Protects Axons after Spinal Cord Injury.Journal of neurotrauma · 2022Article
- High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor.Structure (London, England : 1993) · 2022Article
- RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation.Acta neuropathologica communications · 2021Article
- "Ryanopathies" and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?Cell death & disease · 2021Review
- Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.Acta neuropathologica · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Renaud BussiereFrom the Université Côte d'Azur, CNRS, IPMC, France, "Labex Distalz," 660 route des Lucioles, 06560 Sophia-Antipolis, Valbonne, France.
Alain LacampagneINSERM U1046, CNRS UMR9214, CNRS LIA1185, Université de Montpellier, CHRU Montpellier, 34295 Montpellier, France, and.
Steven ReikenDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, New York 10032.
Xiaoping LiuDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, New York 10032.
Valerie ScheuermanINSERM U1046, CNRS UMR9214, CNRS LIA1185, Université de Montpellier, CHRU Montpellier, 34295 Montpellier, France, and.
Ran ZalkDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, New York 10032.
Cécile MartinFrom the Université Côte d'Azur, CNRS, IPMC, France, "Labex Distalz," 660 route des Lucioles, 06560 Sophia-Antipolis, Valbonne, France.
Frederic CheclerFrom the Université Côte d'Azur, CNRS, IPMC, France, "Labex Distalz," 660 route des Lucioles, 06560 Sophia-Antipolis, Valbonne, France.
Andrew R MarksDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, New York 10032 arm42@columbia.edu.
Mounia ChamiFrom the Université Côte d'Azur, CNRS, IPMC, France, "Labex Distalz," 660 route des Lucioles, 06560 Sophia-Antipolis, Valbonne, France, mchami@ipmc.cnrs.fr.
Columbia University · USCentre National de la Recherche Scientifique · FRInserm · FRInstitut de Pharmacologie Moléculaire et Cellulaire · FR
Funding
MOLECULAR BASIS OF HEART FAILURER01HL061503 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 1998 to 2016
$6.5MTraining in Cardiovascular Translational ResearchT32HL120826 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, TABAS, IRA A · 2014 to 2023
$4.7MIntracellular calcium leak and muscle functionR01AR060037 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2010 to 2014
$1.7MNovel Therapeutic Approaches to Atrial Fibrillation Targeting Intracellular CalciR01HL102040 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2011 to 2014
$1.6MSummer Program for Under Represented Students (SPURS)R25NS076445 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wesley B Grueber, STEVEN A SIEGELBAUM · 2012 to 2026
$1.4MNHLBI NIH HHS R01 HL061503NHLBI NIH HHS R01 HL102040NHLBI NIH HHS T32 HL120826NIAMS NIH HHS R01 AR060037NINDS NIH HHS R25 NS076445
Abstract
Alteration of ryanodine receptor (RyR)-mediated calcium (Ca
Indexed as
Calcium SignalingProtein Processing, Post-TranslationalAdrenergic beta-2 Receptor AntagonistsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCell Line, TumorCyclic AMP-Dependent Protein KinasesEnzyme ActivationHumansMutationNerve Tissue ProteinsNeuronsOxidation-ReductionOxidative StressPhosphorylationADRB2 protein, humanAdrenergic beta-2 Receptor AntagonistsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAPP protein, humanCyclic AMP-Dependent Protein KinasesNerve Tissue ProteinsReceptors, Adrenergic, beta-2Recombinant ProteinsRyanodine Receptor Calcium Release ChannelRyR2 protein, humantacrolimus binding protein 1BTacrolimus Binding ProteinsAlzheimer diseaseamyloid precursor protein (APP)amyloid-β (AB)calcium intracellular releasecalstabin2ryanodine receptorβ 2 adrenergic signaling
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.