Evidence map›Paper›PMID 28476885›Full record

ArticleThe Journal of biological chemistry2017

Small teams of myosin Vc motors coordinate their stepping for efficient cargo transport on actin bundles.

Elena B Krementsova, Ken'ya Furuta, Kazuhiro Oiwa, Kathleen M Trybus, M Yusuf Ali

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Elena B KrementsovaFrom the Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405 and.
Ken'ya Furutathe Advanced ICT Research Institute, National Institute of Information and Communications Technology, Kobe 651-2492, Japan.
Kazuhiro Oiwathe Advanced ICT Research Institute, National Institute of Information and Communications Technology, Kobe 651-2492, Japan.
Kathleen M TrybusFrom the Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405 and kathleen.trybus@uvm.edu.
M Yusuf AliFrom the Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405 and yusuf.ali@med.uvm.edu.
University of Vermont · USNational Institute of Information and Communications Technology · JP

Funding

MUTATIONAL STUDIES OF PROCESSIVE MYOSIN MOTORSR01GM078097 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TRYBUS, KATHLEEN M · 2007 to 2019
$4.8M
NIGMS NIH HHS R01 GM078097
6 · The paper itself

Abstract

Myosin Vc (myoVc) is unique among vertebrate class V myosin isoforms in that it requires teams of motors to move continuously on single actin filaments. Single molecules of myoVc cannot take multiple hand-over-hand steps from one actin-binding site to the next without dissociating, in stark contrast to the well studied myosin Va (myoVa) isoform. At low salt, single myoVc motors can, however, move processively on actin bundles, and at physiologic ionic strength, even teams of myoVc motors require actin bundles to sustain continuous motion. Here, we linked defined numbers of myoVc or myoVa molecules to DNA nanostructures as synthetic cargos. Using total internal reflectance fluorescence microscopy, we compared the stepping behavior of myoVc

Indexed as

Actin CytoskeletonAnimalsBiological Transport, ActiveMiceMyosin Heavy ChainsMyosin Type VQuantum DotsSecretory VesiclesMyo5a protein, mouseMyosin Heavy ChainsMyosin Type Vimagingmolecular motormyosinprotein expressionsingle-molecule biophysics

Identifiers

PMID28476885
PMCPMC5491783
OpenAlexW2952226446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.