Evidence map›Paper›PMID 28476663›Full record

ArticleNeuroImage2018

A probabilistic template of human mesopontine tegmental nuclei from in vivo 7T MRI.

Marta Bianciardi, Christian Strong, Nicola Toschi, Brian L Edlow, Bruce Fischl, Emery N Brown, Bruce R Rosen, Lawrence L Wald

Abstract read
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Intensity-dependent topographical expansion of sensory representations.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026
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  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. PET Imaging of the Human Brain with Microvolumetric Spatial Resolution.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  12. Article
  13. Biomarker changes associated with fornix deep brain stimulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Marta BianciardiDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: martab@mgh.harvard.edu.
Christian StrongDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: cstrong2@partners.org.
Nicola ToschiDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States; Medical Physics Section, Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome "Tor Vergata", Rome, Italy. Electronic address: toschi@med.uniroma2.it.
Brian L EdlowDepartment of Neurology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: bedlow@mgh.harvard.edu.
Bruce FischlDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States; HST/CSAIL, MIT, Cambridge, MA, United States. Electronic address: fischl@nmr.mgh.harvard.edu.
Emery N BrownDepartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, United States; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, United States; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States; MIT-Harvard Health Science and Technology, Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States. Electronic address: enb@neurostat.mit.edu.
Bruce R RosenDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: bruce@nmr.mgh.harvard.edu.
Lawrence L WaldDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Electronic address: wald@nmr.mgh.harvard.edu.
Athinoula A. Martinos Center for Biomedical Imaging · USHarvard University · USBrigham and Women's Hospital · USMassachusetts Institute of Technology · USUniversity of Rome Tor Vergata · IT

Funding

EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo DiagnosticsU01NS086625 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2017
$6.1M
FreeSurfer Development, Maintenance, and HardeningR01EB023281 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Douglas Nowlin Greve · 2016 to 2026
$5.6M
A Longitudinal Analysis Stream for FreeSurferR01NS083534 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2014 to 2026
$4.6M
Algorithms for MR and OCT-based Architectonic and Laminar SegmentationR01EB019956 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2015 to 2018
$2.4M
Software Tools for Automated Modeling of White Matter Fascicles from Diffusion MRR01NS070963 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2011 to 2015
$2.3M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
Inferring in Vivo Cytoarchitectural Borders in the Medial Temporal LobeR01EB006758 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2007 to 2010
$1.9M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIBIB NIH HHS K01 EB019474NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB006758NIBIB NIH HHS R01 EB019956NIBIB NIH HHS R01 EB023281NIBIB NIH HHS R21 EB018907NIMH NIH HHS U01 MH093765NINDS NIH HHS K23 NS094538NINDS NIH HHS R01 NS070963NINDS NIH HHS R01 NS083534NINDS NIH HHS R21 NS072652NINDS NIH HHS U01 NS086625
6 · The paper itself

Abstract

Mesopontine tegmental nuclei such as the cuneiform, pedunculotegmental, oral pontine reticular, paramedian raphe and caudal linear raphe nuclei, are deep brain structures involved in arousal and motor function. Dysfunction of these nuclei is implicated in the pathogenesis of disorders of consciousness and sleep, as well as in neurodegenerative diseases. However, their localization in conventional neuroimages of living humans is difficult due to limited image sensitivity and contrast, and a stereotaxic probabilistic neuroimaging template of these nuclei in humans does not exist. We used semi-automatic segmentation of single-subject 1.1mm-isotropic 7T diffusion-fractional-anisotropy and T

Indexed as

AdultDiffusion Tensor ImagingEcho-Planar ImagingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeuroimagingTegmentum MesencephaliAscending arousal and motor systemsCuneiform/pedunculotegmental/oral pontine reticular/paramedian raphe/caudal linear raphe nucleiHuman mesopontine tegmental nucleiIn vivo neuroimaging templateMulti-contrast 7T MRI

Identifiers

PMID28476663
PMCPMC5670016
OpenAlexW2611077087

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.