ArticleThe American journal of emergency medicine2017
Emergency department visits involving benzodiazepines and non-benzodiazepine receptor agonists.
Article in The American journal of emergency medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Association Between Sedative-Hypnotic Medication Use and Fall-Related Emergency Department Visits Among Older Adults.Cureus · 2026Article
- Screening criteria of potentially inappropriate medications and associations of exposure timing with incident hospital admissions among older adults in a rural community hospital.BMC geriatrics · 2025Article
- A Two-year Retrospective Observational Cohort Study of Benzodiazepine Overdose Cases in the Emergency Department.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Incident gabapentin prescribing associated with opioid and benzodiazepine/Z-drug prescribing - a population-based longitudinal study in primary care.Frontiers in pharmacology · 2025Article
- Fall Outcomes in Older Adults Following Benzodiazepine/Z-Drug Discontinuation: A Retrospective Cohort Study in an Academic Health System.Drugs & aging · 2024Article
- Central nervous system medication use around hospitalization.Journal of the American Geriatrics Society · 2024Article
- Unintentional drug-related deaths in people with mental illness in NSW Australia, 2012-2016: a retrospective cohort study.Social psychiatry and psychiatric epidemiology · 2023Article
- Hospitalisations related to benzodiazepine, Z-drug, and opioid treatment in Italy: a claim on the risks associated with inappropriate use.European journal of clinical pharmacology · 2022Article
- Overdose deaths involving non-BZD hypnotic/sedatives in the USA: Trends analyses.Lancet regional health. Americas · 2022Article
- Trends in Prescriptions for Insomnia in a Province in China Between 2015 and 2019.Frontiers in psychiatry · 2022Article
- Sex differences in US emergency department non-fatal visits for benzodiazepine poisonings in adolescents and young adults.Drug and alcohol dependence · 2021Article
- Risk of hospitalisation associated with benzodiazepines and z-drugs in Italy: a nationwide multicentre study in emergency departments.Internal and emergency medicine · 2020Article
- Removing abuse-prone prescription medication from fueling the national opioid crisis through community engagement and surgeon leadership: results of a local drug take-back event.Surgery open science · 2020Article
- Sedative-hypnotic initiation and renewal at discharge in hospitalized older patients: an observational study.BMC geriatrics · 2018Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveSedative-hypnotic medications (e.g., Benzodiazepines [BZDs] and non-benzodiazepine receptor agonists [nBZRAs]) are associated with adverse events, especially in the elderly, that may require emergency department (ED) treatment. This study assessed outcomes from ED visits attributed to BZDs and/or nBZRAs, and variations in these associations by age group.
methodsData came from the 2004-2011 waves of the Drug Abuse Warning Network (DAWN). Visits were categorized as involving: (1) BZDs-only, (2) nBZRAs-only, (3) combination of BZDs and nBZRAs, or (4) any other sedative-hypnotic medication. DAWN also recorded the disposition (i.e., outcome) of the visit. Analyses focused on outcomes indicating a serious disposition defined as hospitalization, patient transfer or death. Using logistic regression, the association of BZD and nBZRA use with visit disposition was assessed after applying sample weights so as to be nationally representative of ED visits in the United States involving medications or illicit substances.
resultsNineteen percent of visits involving other sedative-hypnotics, 28% involving BZDs-only, 20% involving nBZRAs-only and 48% involving a combination of BZDs and nBZRAs resulted in a serious disposition. Compared to visits involving other sedative-hypnotics, visits involving BZDs-only had 66% greater odds (Odds Ratio [OR]=1.66, 95% Confidence Interval [CI]=1.37-2.01), and visits involving a combination of BZDs and nBZRAs had almost four times increased odds of a serious disposition (OR=3.91, 95% CI=2.38-6.41). Results were similar across age groups.
conclusionsFindings highlight the need for clinical and regulatory initiatives to reduce BZD use, especially in combination with nBZRAs, and to promote treatment with safer alternatives to these medications.
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