Evidence map›Paper›PMID 28476436›Full record

ReviewClinical immunology (Orlando, Fla.)2017

Genetics of Sjögren's syndrome.

Leyla Y Teos, Ilias Alevizos

Abstract readReview
In one paragraph

Review in Clinical immunology (Orlando, Fla.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Variants inInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
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  11. Review
  12. Review
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  14. Review
  15. Article
  16. Article
  17. X-linked genes exhibit miR6891-5p-regulated skewing in Sjögren's syndrome.Journal of molecular medicine (Berlin, Germany) · 2022
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Leyla Y TeosSjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Ilias AlevizosSjögren's Syndrome and Salivary Gland Dysfunction Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Electronic address: alevizosi@mail.nih.gov.

Funding

Clinical Investigations of Sjogren's SyndromeZIADE000704 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WARNER, BLAKE · 2009 to 2025
$22.3M
Intramural NIH HHS Z99 DE999999Intramural NIH HHS ZIA DE000704
6 · The paper itself

Abstract

The pathogenesis of Sjögren's syndrome has not been elucidated. There has been evidence that genetics play an important role in the development of this disease from earlier studies. However, till now only a number of genes have been identified to be associated with SS, and these have only a weak or moderate effect. In this review we summarize the findings of the genetics studies and emphasize the need of large multicenter projects that will increase the sample sizes to provide more meaningful associations, as is the case in other common autoimmune diseases.

Indexed as

B-Cell Activating FactorChemokine CCL11DNA-Binding ProteinsGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA AntigensHumansInterferon Regulatory FactorsInterleukin-12 Subunit p35Lymphotoxin-alphaNatural Cytotoxicity Triggering Receptor 3OX40 LigandReceptors, CXCR5Serotonin Plasma Membrane Transport ProteinsSjogren's Syndromesrc-Family KinasesB-Cell Activating FactorBLK protein, humanCCL11 protein, humanChemokine CCL11CXCR5 protein, humanDNA-Binding ProteinsEBF1 protein, humanGTF2I protein, humanHLA AntigensIL12A protein, humanInterferon Regulatory FactorsInterleukin-12 Subunit p35IRF5 protein, humanLymphotoxin-alphaNatural Cytotoxicity Triggering Receptor 3NCR3 protein, humanOX40 LigandReceptors, CXCR5Serotonin Plasma Membrane Transport Proteinssrc-Family KinasesSTAT4 protein, humanSTAT4 Transcription FactorTNFAIP3 protein, humanTNFSF13B protein, humanTNFSF4 protein, humanTNIP1 protein, humanTrans-ActivatorsTranscription Factors, TFIITumor Necrosis Factor alpha-Induced Protein 3

Identifiers

PMID28476436
PMCPMC5660941

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.