Evidence map›Paper›PMID 28476320›Full record

ArticleNeuroscience2017

Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using

Małgorzata Marjańska, J Riley McCarten, James Hodges, Laura S Hemmy, Andrea Grant, Dinesh K Deelchand, Melissa Terpstra

Abstract read
In one paragraph

Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Neurobiology of aging · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Simultaneous Concentration and TNMR in biomedicine · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Faster bi-stable visual switching in psychosis.Translational psychiatry · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Małgorzata MarjańskaCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6th ST SE, Minneapolis, MN 55455, United States. Electronic address: gosia@cmrr.umn.edu.
J Riley McCartenGeriatric Research, Education and Clinical Center, Veterans Affairs Health Care System, 1 Veterans Drive, Minneapolis, MN 55417, United States; Department of Neurology, University of Minnesota, 12-112 PWB, 516 Delaware ST SE, Minneapolis, MN 55455, United States.
James HodgesDivision of Biostatistics, School of Public Health, University of Minnesota, 2221 University Ave, Minneapolis, MN 55414, United States.
Laura S HemmyGeriatric Research, Education and Clinical Center, Veterans Affairs Health Care System, 1 Veterans Drive, Minneapolis, MN 55417, United States; Department of Psychiatry, University of Minnesota, F282/2A West, 2450 Riverside Ave S, Minneapolis, MN 55454, United States.
Andrea GrantDepartment of Neuroscience, University of Minnesota, 321 Church ST SE, Minneapolis, MN 55455, United States.
Dinesh K DeelchandCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6th ST SE, Minneapolis, MN 55455, United States.
Melissa TerpstraCenter for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6th ST SE, Minneapolis, MN 55455, United States.

Funding

NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Noninvasive Antioxidant Quantification in the Human Brain under Oxidative StressR01AG039396 · NIA · UNIVERSITY OF MINNESOTA · PI TERPSTRA, MELISSA J · 2012 to 2016
$1.6M
NIA NIH HHS R01 AG039396NIBIB NIH HHS P41 EB015894NINDS NIH HHS P30 NS076408
6 · The paper itself

Abstract

The concentrations of fourteen neurochemicals associated with metabolism, neurotransmission, antioxidant capacity, and cellular structure were measured noninvasively from two distinct brain regions using

Indexed as

Brain ChemistryMagnetic Resonance SpectroscopyAgedAged, 80 and overAgingAscorbic AcidAspartic AcidCreatineDipeptidesFemaleGlutamic AcidGyrus CinguliHumansMaleOccipital LobePhosphocreatineAscorbic AcidAspartic AcidCreatineDipeptidesGlutamic Acidisospaglumic acidN-acetylaspartatePhosphocreatineTritiumagingcellularhuman brainmagnetic resonance spectroscopyneurochemicalsnoninvasive

Identifiers

PMID28476320
PMCPMC5516630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.