Evidence map›Paper›PMID 28475888›Full record

ArticleCell2017

Ribosomes Need Straight A's to Sleep.

Samuel B Sondalle, Susan J Baserga

Registry-linked trialAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07281716 (A Phase 1b/2 Study of Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic Microsatellite Stable), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07281716 phase1 / phase2recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase 1b/2 Study of Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC)

TypeinterventionalSponsorDan FengRan2025 to 2028Enrolled24ConditionsMetastatic Microsatellite Stable Colorectal CarcinomaArmsNadunolimab, Toripalimab
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Samuel B SondalleDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Susan J BasergaDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA; Department Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: susan.baserga@yale.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
GENETICS AND GENOMICS OF HUMAN DISEASET32HD007149 · NICHD · YALE UNIVERSITY · PI James P Noonan · 1985 to 2026
$8.2M
Key factors in human ribosome biogenesisR01GM115710 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 2015 to 2018
$1.6M
Probing the Pathogenesis of North American Indian Childhood Cirrhosis (NAIC)F30DK109582 · NIDDK · YALE UNIVERSITY · PI SONDALLE, SAMUEL BRADY · 2016 to 2017
$57k
NICHD NIH HHS T32 HD007149NIDDK NIH HHS F30 DK109582NIGMS NIH HHS R01 GM115710NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Like falling asleep and waking up, many biological processes in mammals cycle in a diurnal fashion. Now, Sinturel et al. demonstrate that diurnal size changes in the liver require eating during a mouse's normal awake time and that these size changes are controlled by a nuclear mechanism that modulates ribosome production.

Indexed as

SleepWakefulnessAnimalsMiceRibosomes

Identifiers

PMID28475888
PMCPMC5640166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.