Evidence map›Paper›PMID 28475732›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.

Evan C Hadley, George A Kuchel, Anne B Newman, Workshop Speakers and Participants

Erratum issued Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06955676 (The Effects of Moderate Intensity, Time-matched Cycle Ergometer vs. Treadmill Exercise Training on Parameters Associated With Physiological Resilience in Older Adults), which is not on this map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06955676 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effects of Moderate Intensity, Time-matched Cycle Ergometer vs. Treadmill Exercise Training on Parameters Associated With Physiological Resilience in Older Adults: A Pilot Study

TypeinterventionalSponsorUniversity of NottinghamRan2024 to 2026Enrolled36ConditionsOlder PeopleArmstreadmill exercise, cycle ergometer exercise
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 159 citations in OpenAlex.

  1. Trial
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  6. Review
  7. Examining the relevance of gait speed resiliencies to different stressors: the ARIC Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Clinical predictors of resilience following total knee arthroplasty: the PRIME-KNEE study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Provocative testing in community dwelling older adults: a path to identify physical resilience.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Review

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 16 institutions in 2 countries.

Evan C HadleyNational Institute on Aging, Bethesda, Maryland.
George A KuchelUniversity of Connecticut, Farmington.
Anne B NewmanGraduate School of Public Health, University of Pittsburgh, Pennsylvania.
Workshop Speakers and Participants
National Institutes of Health · USDuke University · USJohns Hopkins University · USUConn Health · USUniversity of Pittsburgh · USGeriatric Research Education and Clinical Center · USHadassah Medical Center · ILMayo Clinic · USStanford University · USUniversity of Connecticut · USUniversity of Michigan · USUniversity of Notre Dame · USUniversity of Washington · USVanderbilt University · USWake Forest University · USYale University · US

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
Effect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6M
Inflammatory Mechanisms Underlie Lysosome Failure in the Aging BrainR01AG058856 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DUGAN, LAURA L · 2018 to 2022
$2.0M
NIA NIH HHS P30 AG024824NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG028716NIA NIH HHS R01 AG058856NIA NIH HHS R37 AG013925
6 · The paper itself

Abstract

BACKGROUND/

objectivesResilience, the ability to resist or recover from adverse effects of a stressor, is of widespread interest in social, psychologic, biologic, and medical research and particularly salient as the capacity to respond to stressors becomes diminished with aging. To date, research on human resilience responses to and factors influencing these responses has been limited.

methodsThe National Institute on Aging convened a workshop in August 2015 on needs for research to improve measures to predict and assess resilience in human aging. Effects of aging-related factors in impairing homeostatic responses were developed from examples illustrating multiple determinants of clinical resilience outcomes. Research directions were identified by workshop participants.

resultsResearch needs identified included expanded uses of clinical data and specimens in predicting or assessing resilience, and contributions from epidemiological studies in identifying long-term predictors. Better measures, including simulation tests, are needed to assess resilience and its determinants. Mechanistic studies should include exploration of influences of biologic aging processes on human resiliencies. Important resource and infrastructure needs include consensus phenotype definitions of specific resiliencies, capacity to link epidemiological and clinical resilience data, sensor technology to capture responses to stressors, better laboratory animal models of human resiliencies, and new analytic methods to understand the effects of multiple determinants of stress responses.

conclusionsExtending the focus of care and research to improving the capacity to respond to stressors could benefit older adults in promoting a healthier life span.

Indexed as

Resilience, PsychologicalAdaptation, PsychologicalAgedAgingBehavioral ResearchConsensus Statements as TopicFemaleGeriatric AssessmentHumansMaleStress, PsychologicalBiologic agingEpidemiologyHuman agingPhysiologic resilience

Identifiers

PMID28475732
PMCPMC5861884
OpenAlexW2611341457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.