ArticlePloS one2017
Genome wide analysis of the evolution of Senecavirus A from swine clinical material and assembly yard environmental samples.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Evolutionary Dynamics and Transboundary Spread of Senecavirus A: The Role of Recombination and Global Swine Trade.Transboundary and emerging diseases · 2026Article
- Phylogeographic Characterizations of Recent (2015-2023) Senecavirus A Isolates from Canada.Viruses · 2025Article
- Identification of linear B-cell epitopes of Senecavirus A VP2 protein using monoclonal antibodies.Frontiers in microbiology · 2025Article
- ZFP36 Facilitates Senecavirus A (SVA) replication by inhibiting the production of type I interferon.Virus research · 2024Article
- VP0 Myristoylation Is Essential for Senecavirus A Replication.Pathogens (Basel, Switzerland) · 2024Article
- circRNA_8521 promotes Senecavirus A infection by sponging miRNA-324 to regulate LC3A.Veterinary research · 2024Article
- A rapid and visual detection assay for Senecavirus A based on recombinase-aided amplification and lateral flow dipstick.Frontiers in cellular and infection microbiology · 2024Article
- Directed Evolution of Seneca Valley Virus in Tumorsphere and Monolayer Cell Cultures of a Small-Cell Lung Cancer Model.Cancers · 2023Article
- Seneca Valley virus 3CFrontiers in microbiology · 2023Review
- The Evolution and Global Spatiotemporal Dynamics of Senecavirus A.Microbiology spectrum · 2022Article
- Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer.Nature communications · 2022Article
- The third wave of Seneca Valley virus outbreaks in pig herds in southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Article
- Characterization of Senecavirus A Isolates Collected From the Environment of U.S. Sow Slaughter Plants.Frontiers in veterinary science · 2022Article
- Article
- Comprehensive phylogeographic and phylodynamic analyses of global Senecavirus A.Frontiers in microbiology · 2022Article
- Advances in the differential molecular diagnosis of vesicular disease pathogens in swine.Frontiers in microbiology · 2022Review
- The game between host antiviral innate immunity and immune evasion strategies of senecavirus A - A cell biological perspective.Frontiers in immunology · 2022Review
- Article
- Construction and Generation of a Recombinant Senecavirus a Stably Expressing the NanoLuc Luciferase for Quantitative Antiviral Assay.Frontiers in microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Senecavirus A (SVA), previously known as Seneca Valley virus, was first isolated in the United States in 2002. SVA was associated with porcine idiopathic vesicular disease in Canada and the USA in 2007 and 2012, respectively. Recent increase in SVA outbreaks resulting in neonatal mortality of piglets and/or vesicular lesions in sows in Brazil, the USA and Canada point to the necessity to study the pathogenicity and molecular epidemiology of the virus. Here, we report the analysis of the complete coding sequences of SVA from 2 clinical cases and 9 assembly yard environmental samples collected in 2015 in Canada, along with 22 previously released complete genomes in the GenBank. With this combined data set, the evolution of the SVA over a 12-month period in 2015/2016 was evaluated. These SVA isolates were characterized by a rapid accumulation of genetic variations driven mainly by a high nucleotide substitution rate and purifying selection. The SVA sequences clustered in clearly defined geographical areas with reported cases of SVA infection. No transmission links were identified between assembly yards, suggesting that point source introductions may have occurred. In addition, 25 fixed non-synonymous mutations were identified across all analyzed strains when compared to the prototype SVA strain (SVV-001). This study highlights the importance of monitoring SVA mutations for their role in increased virulence and impact on SVA diagnostics.
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