Evidence map›Paper›PMID 28475594›Full record

ArticlePloS one2017

Development of heterotopic transplantation of the testis with the epididymis to evaluate an aspect of testicular immunology in rats.

Kai Yi, Naoyuki Hatayama, Shuichi Hirai, Ning Qu, Shogo Hayashi, Shinichi Kawata, Kenta Nagahori, Munekazu Naito, Masahiro Itoh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Immunological microenvironment in the testis.Reproductive medicine and biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kai YiDepartment of Anatomy, Tokyo Medical University, Tokyo, Japan.
Naoyuki HatayamaDepartment of Anatomy, Tokyo Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3652-1046
Shuichi HiraiDepartment of Anatomy, Aichi Medical University, Aichi, Japan.
Ning QuDepartment of Anatomy, Tokyo Medical University, Tokyo, Japan.
Shogo HayashiDepartment of Anatomy, Tokyo Medical University, Tokyo, Japan.
Shinichi KawataDepartment of Anatomy, Tokyo Medical University, Tokyo, Japan.
Kenta NagahoriDepartment of Anatomy, Tokyo Medical University, Tokyo, Japan.
Munekazu NaitoDepartment of Anatomy, Aichi Medical University, Aichi, Japan.
Masahiro ItohDepartment of Anatomy, Tokyo Medical University, Tokyo, Japan.
Tokyo Medical University · JPAichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transplantation of testicular cells and tissues has been studied for the investigation of immunology of the testis, which is an immunologically privileged organ. However, reports of transplant of the testis at organ level have been extremely limited because of technical difficulties of the orthotopic testis transplantation (OTT) in experimental animals. In the present study, we developed a new and simple model of the heterotopic testis transplantation (HTT), which is donor testis transplantation into the cervical region of recipients, in a syngeneic model in rats [donor Lewis (LEW) graft to LEW recipient]. The duration of HTT was significantly shorter and success rate higher than that of OTT. To histologically evaluate HTT, the local immune responses were compared among the syngeneic model, an acute rejection allogeneic model [donor Augustus Copenhagen Irish (ACI) graft to LEW recipient] and a chronic rejection allogeneic model (donor F344 graft to LEW recipient) at postoperative day 3. We found that allogeneic ACI grafts resulted in mild and not severe orchitic lesions, whereas immune responses of allogeneic F344 grafts seemed intact and were not significantly different from those of syngeneic LEW grafts. These results suggest that our new operative procedure will be useful in future for the investigation of the testicular immunology.

Indexed as

AnimalsEpididymisMaleRatsTestisTransplantation, Heterotopic

Identifiers

PMID28475594
PMCPMC5419600
OpenAlexW2610854727

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.