ArticlePloS one2017
Sarcoidosis in an Italian province. Prevalence and environmental risk factors.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 51 citations in OpenAlex.
- Occupational exposures in sarcoidosis: a protocol for a multicentre regional case-control study in the UK.BMJ open respiratory research · 2025Article
- Fibrotic Pulmonary Sarcoidosis-From Pathogenesis to Management.Journal of clinical medicine · 2025Review
- Pathogenetic Mechanisms Linking Sarcoidosis to Lymphoma.International journal of molecular sciences · 2025Review
- Identifying sarcoidosis trends using web search and real-world data in Sweden: a retrospective longitudinal study.Scientific reports · 2024Article
- Association between sarcoidosis and cardiovascular Outcomes: A systematic review and Meta-analysis.International journal of cardiology. Heart & vasculature · 2022Article
- Sarcoid Uveitis: An Intriguing Challenger.Medicina (Kaunas, Lithuania) · 2022Review
- Nasopharyngeal sarcoidosis: case reports and literature review.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2022Article
- The position of geochemical variables as causal co-factors of diseases of unknown aetiology.SN applied sciences · 2022Review
- Sarcoidosis in Johannesburg, South Africa: A retrospective study.African journal of thoracic and critical care medicine · 2022Article
- Leveraging internet search data to assess prevalence, interest, and unmet needs of sarcoidosis in Germany.Scientific reports · 2021Article
- A Primer on the Clinical Aspects of Sarcoidosis for the Basic and Translational Scientist.Journal of clinical medicine · 2021Review
- Renal involvement in sarcoidosis: histological patterns and prognosis, an Italian survey.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2021Article
- Are infectious diseases risk factors for sarcoidosis or a result of reverse causation? Findings from a population-based nested case-control study.European journal of epidemiology · 2020Article
- Delphi consensus recommendations for a treatment algorithm in pulmonary sarcoidosis.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Incidence and economic burden of sarcoidosis in years 2011-2015 in Silesian voivodeship, Poland.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2020Article
- Review
- Epidemiology of sarcoidosis: current findings and future directions.Therapeutic advances in chronic disease · 2018Review
- Prevalence and incidence of sarcoidosis in Korea: a nationwide population-based study.Respiratory research · 2018Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimSarcoidosis is a systemic granulomatous inflammatory disease whose causes are still unknown and for which epidemiological data are often discordant. The aim of our study is to investigate prevalence and spatial distribution of cases, and identify environmental exposures associated with sarcoidosis in an Italian province.
methodsAfter georeferentiation of cases, the area under study was subdivided with respect to Municipality and Health Districts and to the altitude in order to identify zonal differences in prevalence. The bioaccumulation levels of 12 metals in lichen tissues were analyzed, in order to determine sources of air pollution. Finally, the analysis of the correlation between metals and between pickup stations was performed.
results223 patients were identified (58.3% female and 41.7% male of total) and the mean age was 50.6±15.4 years (53.5±15.5 years for the females and 46.5±14.4 for the males). The mean prevalence was 49 per 100.000 individuals. However, we observed very heterogeneous prevalence in the area under study. The correlations among metals revealed different deposition patterns in lowland area respect to hilly and mountain areas.
conclusionsThe study highlights a high prevalence of sarcoidosis cases, characterized by a very inhomogeneous and patchy distribution with phenomena of local aggregation. Moreover, the bioaccumulation analysis was an effective method to identify the mineral particles that mostly contribute to air pollution in the different areas, but it was not sufficient to establish a clear correlation between the onset of sarcoidosis and environmental risk factors.
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