ArticlePloS one2017
Neural substrate of posterior left atrium: A novel modulation for inducibility and remodeling of atrial fibrillation in canine.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- The cardiac autonomic nervous system: A target for modulation of atrial fibrillation.Clinical cardiology · 2019Review
- Analysis of Haematological and Biochemical Blood Parameters After Electrical Cardioversion of Atrial Fibrillation in Dogs.Journal of veterinary research · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neural mechanism of posterior left atrium (PLA) for genesis of atrial fibrillation has not been completely elucidated. We sought to assess the contribution of PLA denervation on atrial fibrillation (AF) inducibility and atrial remodeling. METHODS AND
resultsAfter left thoracotomy in anesthetized dogs (n = 32), electrode catheters were attached to the PLA, left atrial roof, left pulmonary vein and left atrial appendage. Experiment 1 (n = 16): Vagal stimulation (VS group, n = 8) led to more pronounced ERP shortening in PLA than in other sites (CTL:71±7 ms vs VS: 52±6 ms, P<0.05;). Compared with control group (CTL group, n = 8), atropine alone or with propranolol applied to PLA greatly inhibited VS-induced ERP shortening, ERP dispersion increase, and AF inducibility in the left atrium (P<0.05); but ERP was not significantly different between atropine alone and DB conditions (Atro:85±8 ms vs DB:90±9ms, P>0.05). In addition, domain frequency (DF) of VS-induced AF waveform was not affected by atropine alone, while selective double autonomic blockade at PLA significantly decreased DF at all sites (P<0.05). Experiment 2 (n = 16): In group 1 (n = 8), ERP was markedly shortened in the first 2 hours (11-19% decrease) and then stabilized; however, WOV was progressively widened throughout the 6 hours rapid atrial pacing (BS: 51±9ms vs 6th hour: 161±30ms, P<0.05). After drug application, ERP was increased in all sites of atria, the ERP dispersion was significantly decreased (Atro: 2.36±0.02 vs 6th hour: 5.09±0.07, P<0.05) and AF could be induced in only 1 of 8 dogs. In group 2 (n = 8), 6 hours rapid atrial pacing failed to shorten the ERP and increased ERP dispersion, and only 2 episodes of AF could be induced (WOV = 0).
conclusionLocal denervation of PLA, as predominant atrial autonomic profile, greatly inhibits AF inducibility and atrial remodeling.
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