ArticlePloS one2017
Age, gender and UV-exposition related effects on gene expression in in vivo aged short term cultivated human dermal fibroblasts.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Dermal fibroblasts cultured from aged human skin display a pro-inflammatory phenotype.Journal of cell communication and signaling · 2026Article
- Cryptic transcription in aging.iScience · 2026Review
- Efficient cryopreservation of Antillean manatee skin-derived somatic cells via reduced intracellular cryoprotectant concentration.In vitro cellular & developmental biology. Animal · 2026Article
- Advances in the application of multi-omics analysis in skin aging.Frontiers in aging · 2025Review
- Biomarkers of UVB radiation-related senescent fibroblasts.Scientific reports · 2024Article
- A Novel In Vitro Wound Healing Assay Using Free-Standing, Ultra-Thin PDMS Membranes.Membranes · 2022Article
- Transcriptome of HPβCD-treated Niemann-Pick disease type C1 cells highlights GPNMB as a biomarker for therapeutics.Human molecular genetics · 2021Article
- Altered Chromatin States Drive Cryptic Transcription in Aging Mammalian Stem Cells.Nature aging · 2021Article
- Ultraviolet light-induced collagen degradation inhibits melanoma invasion.Nature communications · 2021Article
- Effects of Natural Antioxidants on Phospholipid and Ceramide Profiles of 3D-Cultured Skin Fibroblasts Exposed to UVA or UVB Radiation.Antioxidants (Basel, Switzerland) · 2021Article
- Profiling of cis- and trans-acting factors supporting noncanonical splice site activation.RNA biology · 2021Article
- Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents.Cancers · 2020Review
- Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis.BMC medical genetics · 2020Article
- Repetitive elements as a transcriptomic marker of aging: Evidence in multiple datasets and models.Aging cell · 2020Article
- Transcriptomics of Tasmanian Devil (Genes · 2019Article
- The effect of aging in primary human dermal fibroblasts.PloS one · 2019Article
- Predicting age from the transcriptome of human dermal fibroblasts.Genome biology · 2018Article
- Ranking noncanonical 5' splice site usage by genome-wide RNA-seq analysis and splicing reporter assays.Genome research · 2018Article
- Hierarchical Clustering of DNA k-mer Counts in RNAseq Fastq Files Identifies Sample Heterogeneities.International journal of molecular sciences · 2018Article
- Signatures of photo-aging and intrinsic aging in skin were revealed by transcriptome network analysis.Aging · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ageing, the progressive functional decline of virtually all tissues, affects numerous living organisms. Main phenotypic alterations of human skin during the ageing process include reduced skin thickness and elasticity which are related to extracellular matrix proteins. Dermal fibroblasts, the main source of extracellular fibrillar proteins, exhibit complex alterations during in vivo ageing and any of these are likely to be accompanied or caused by changes in gene expression. We investigated gene expression of short term cultivated in vivo aged human dermal fibroblasts using RNA-seq. Therefore, fibroblast samples derived from unaffected skin were obtained from 30 human donors. The donors were grouped by gender and age (Young: 19 to 25 years, Middle: 36 to 45 years, Old: 60 to 66 years). Two samples were taken from each donor, one from a sun-exposed and one from a sun-unexposed site. In our data, no consistently changed gene expression associated with donor age can be asserted. Instead, highly correlated expression of a small number of genes associated with transforming growth factor beta signalling was observed. Also, known gene expression alterations of in vivo aged dermal fibroblasts seem to be non-detectable in cultured fibroblasts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.