Evidence map›Paper›PMID 28475114›Full record

ArticleInternational journal of molecular sciences2017

Melatonin and Vitamin D Interfere with the Adipogenic Fate of Adipose-Derived Stem Cells.

Valentina Basoli, Sara Santaniello, Sara Cruciani, Giorgio Carlo Ginesu, Maria Laura Cossu, Alessandro Palmerio Delitala, Pier Andrea Serra, Carlo Ventura, Margherita Maioli

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Article
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  6. Effects of the MCF-7 Exhausted Medium on hADSC Behaviour.International journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. Effect of vitamin D deficiency on metabolic syndrome among Korean shift workers.Scandinavian journal of work, environment & health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Valentina BasoliDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. valebasoli@gmail.com.
Sara SantanielloDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. sara.santaniello@gmail.com.
Sara CrucianiDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. sara.cruciani@outlook.com.
Giorgio Carlo GinesuClinical and Experimental Medicine Department, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy. ginesugc@uniss.it.
Maria Laura CossuClinical and Experimental Medicine Department, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy. mlcossu@uniss.it.
Alessandro Palmerio DelitalaAzienda Ospedaliero-Universitaria di Sassari, Viale San Pietro 8, 07100 Sassari, Italy. adelitala@tiscali.it.
Pier Andrea SerraClinical and Experimental Medicine Department, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy. paserra@uniss.it.
Carlo VenturaLaboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Via Massarenti, 40138 Bologna, Italy. ventura.vid@gmail.com.
Margherita MaioliDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. mmaioli@uniss.it.
University of Sassari · ITAzienda Ospedaliero Universitaria di Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose-derived stem cells (ADSCs) represent one of the cellular populations resident in adipose tissue. They can be recruited under certain stimuli and committed to become preadipocytes, and then mature adipocytes. Controlling stem cell differentiation towards the adipogenic phenotype could have a great impact on future drug development aimed at counteracting fat depots. Stem cell commitment can be influenced by different molecules, such as melatonin, which we have previously shown to be an osteogenic inducer. Here, we aimed at evaluating the effects elicited by melatonin, even in the presence of vitamin D, on ADSC adipogenesis assessed in a specific medium. The transcription of specific adipogenesis orchestrating genes, such as

Indexed as

AdipogenesisAdipose TissueAdultAdult Stem CellsAntioxidantsCells, CulturedFemaleHumansLipid MetabolismLipoprotein LipaseMaleMelatoninMiddle AgedPPAR gammaThiolester HydrolasesVitamin DACOT2 protein, humanAntioxidantsLipoprotein LipaseMelatoninPPAR gammaThiolester HydrolasesVitamin DVitaminsadipogenesisadipose tissuecell differentiationfat depotmelatoninnutraceuticalsstem cellsvitamin D

Identifiers

PMID28475114
PMCPMC5454894
OpenAlexW2611534638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.