Evidence map›Paper›PMID 28475081›Full record

SynthesisGeneral dentistry

Effectiveness of silver diamine fluoride in caries prevention and arrest: a systematic literature review.

Violeta Contreras, Milagros J Toro, Augusto R Elías-Boneta, Angeliz Encarnación-Burgos

Registry-linked trialOpen access · greenAbstract readSystematic Review
PubMed Full text at PMC
In one paragraph

Synthesis in General dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05438381 (Assistant Lecturer of Pediatric Dentistry, Mansoura University), which is not on this map. Cited by 90 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 8 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05438381 nacompletednot on this map

Assistant Lecturer of Pediatric Dentistry, Mansoura University (2019)

TypeinterventionalSponsorMansoura UniversityRan2019 to 2021Enrolled30ConditionsDental CariesArmsAtraumatic Restorative Technique (ART), SMART Technique
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 8 syntheses or guidelines pooled it, 177 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: randomized clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021
    Trial
  14. Trial
  15. Knowledge, attitude and practice of paediatric dentists towards silver diammine fluoride in Egypt: a national survey.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Violeta Contreras
Milagros J Toro
Augusto R Elías-Boneta
Angeliz Encarnación-Burgos

Funding

Hispanics in Research Capability: SoHP & SOM Partnership (HIREC)S21MD001830 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ELIAS BONETA, AUGUSTO R, ESTAPE, ESTELA S · 2005 to 2010
$30.0M
Hispanic Clinical and Translational Research Education and Career Development ProgramR25MD007607 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Karen G. Martinez Gonzalez, Barbara Segarra-Vazquez · 2012 to 2026
$7.4M
NIMHD NIH HHS R25 MD007607NIMHD NIH HHS S21 MD001830
6 · The paper itself

Abstract

This study aimed to evaluate the scientific evidence regarding the effectiveness of silver diamine fluoride (SDF) in preventing and arresting caries in the primary dentition and permanent first molars. A systematic review (SR) was performed by 2 independent reviewers using 3 electronic databases (PubMed, ScienceDirect, and Scopus). The database search employed the following key words: "topical fluorides" AND "children" AND "clinical trials"; "topical fluorides" OR "silver diamine fluoride" AND "randomized controlled trial"; "silver diamine fluoride" AND "children" OR "primary dentition" AND "tooth decay"; "silver diamine fluoride" OR "sodium fluoride varnish" AND "early childhood caries"; and "silver diamine fluoride" AND "children". Inclusion criteria were articles published in English, from 2005 to January 2016, on clinical studies using SDF as a treatment intervention to evaluate caries arrest in children with primary dentition and/or permanent first molars. Database searches provided 821 eligible publications, of which 33 met the inclusion criteria. After the abstracts were prescreened, 25 articles were dismissed based on exclusion criteria. The remaining 8 full-text articles were assessed for eligibility. Of these, 7 publications were included in the SR. These included 1 study assessing the effectiveness of SDF at different concentrations; 3 studies comparing SDF with other interventions; 2 investigations comparing SDF at different application frequencies and with other interventions; and 1 study comparing semiannual SDF applications versus a control group. The literature indicates that SDF is a preventive treatment for dental caries in community settings. At concentrations of 30% and 38%, SDF shows potential as an alternative treatment for caries arrest in the primary dentition and permanent first molars. To establish guidelines, more studies are needed to fully assess the effectiveness of SDF and to determine the appropriate application frequency.

Indexed as

Cariostatic AgentsChildDental CariesFluorides, TopicalHumansMolarQuaternary Ammonium CompoundsSilver CompoundsTooth, DeciduousCariostatic AgentsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluoride

Identifiers

PMID28475081
PMCPMC5535266
OpenAlexW2980574521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.